The overall goals of this K24 application are to provide Emily Oken MD, MPH with protected time to serve as a mentor to junior clinician investigators, and to support new scientific aims that will build upon Dr. Oken's established work on the lifecourse health effects of maternal perinatal health and nutrition. Dr. Oken is an Associate Professor in the Department of Population Medicine at Harvard Medical School, and a Primary Care Physician at the Gretchen and Edward Fish Center for Women's Health at Brigham and Women's Hospital. She leads several large patient-oriented research studies, including an NICHD-funded R01 of over 14,000 11-year-old children previously enrolled in a randomized trial of breastfeeding intervention;an ongoing NIEHS-funded R01 of maternal prenatal fish consumption, mercury exposure, and child development at age 7 years;and a CDC-funded project to develop an electronic medical record-based system to support gestational weight gain counseling and tracking. Dr. Oken has already successfully served as a research mentor to more than a dozen clinicians in training and PhD candidates. This K24 award would come at a critical time in Dr. Oken's career, as she solidifies her independent research trajectory and seeks to increase her availability to mentor junior investigators. The award will also support a new research investigation that builds on Dr. Oken's ongoing NIH supported work in maternal perinatal nutrition and offspring health. Early studies on the life course effects of early life nutrition focused on poor growth and under nutrition. More recently, a variety of research findings provide substantive evidence that prenatal over nutrition, including exposure to excesses of maternal weight, gestational glucose, and weight gain, is associated with overweight in offspring. However, extant human studies are limited in that few have included outcome measures other than weight. The proposed scientific aims will take advantage of existing data from Project Viva, a unique US pre-birth cohort study of which Dr. Oken is the co-Principal Investigator, to determine the extent to which maternal weight, gestational weight gain, and gestational glucose tolerance are each associated with adiposity and established measures of cardio- metabolic risk among children at age 7 years. This project will also identify novel metabolic markers in children's plasma at age 7 years, using comprehensive metabolic profiling (""""""""metabolomics""""""""), that are associated with maternal prenatal over nutrition and with child adiposity and standard cardio-metabolic risk factors at the same time point.

Public Health Relevance

One out of every three women who become pregnant in the US is obese, and the prevalence of both gestational diabetes mellitus and excess gestational weight gains are each high and rising. These conditions have implications not only for pregnancy outcomes and long-term maternal health, but also for child health. The proposed project will better characterize the child health risks associated with maternal perinatal over nutrition.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Raiten, Daniel J
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Harvard Pilgrim Health Care, Inc.
United States
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Fleisch, Abby F; Rifas-Shiman, Sheryl L; Mora, Ana M et al. (2016) Early Life Exposure to Perfluoroalkyl Substances and Childhood Metabolic Function. Environ Health Perspect :
Perng, Wei; Rifas-Shiman, Sheryl L; Kramer, Michael S et al. (2016) Early Weight Gain, Linear Growth, and Mid-Childhood Blood Pressure: A Prospective Study in Project Viva. Hypertension 67:301-8
Stratakis, Nikos; Roumeliotaki, Theano; Oken, Emily et al. (2016) Fish Intake in Pregnancy and Child Growth: A Pooled Analysis of 15 European and US Birth Cohorts. JAMA Pediatr 170:381-90
Gaillard, Romy; Rifas-Shiman, Sheryl L; Perng, Wei et al. (2016) Maternal inflammation during pregnancy and childhood adiposity. Obesity (Silver Spring) 24:1320-7
Hivert, Marie-France; Rifas-Shiman, Sheryl L; Gillman, Matthew W et al. (2016) Greater early and mid-pregnancy gestational weight gains are associated with excess adiposity in mid-childhood. Obesity (Silver Spring) 24:1546-53
Morisaki, Naho; Kawachi, Ichiro; Oken, Emily et al. (2016) Parental Characteristics can Explain Why Japanese Women Give Birth to the Smallest Infants in the United States. Paediatr Perinat Epidemiol 30:473-8
Sen, Sarbattama; Rifas-Shiman, Sheryl L; Shivappa, Nitin et al. (2016) Dietary Inflammatory Potential during Pregnancy Is Associated with Lower Fetal Growth and Breastfeeding Failure: Results from Project Viva. J Nutr 146:728-36
Chang, Matthew S; Barton, Kerri; Crockett, Molly et al. (2016) Postpartum Laboratory Follow-up in Women With Hepatitis B in Massachusetts From 2007 to 2012. J Clin Gastroenterol 50:e60-4
Oken, Emily; Rifas-Shiman, Sheryl L; Amarasiriwardena, Chitra et al. (2016) Maternal prenatal fish consumption and cognition in mid childhood: Mercury, fatty acids, and selenium. Neurotoxicol Teratol 57:71-78
Kong, K L; Gillman, M W; Rifas-Shiman, S L et al. (2016) Leisure time physical activity before and during mid-pregnancy and offspring adiposity in mid-childhood. Pediatr Obes 11:81-7

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