This grant will fund a mentee training program in the Program on Prevention Outcomes and Practices (PPOP) in the Stanford Prevention Research Center at the Stanford School of Medicine. The training program will be directed by Randall S. Stafford, MD, PhD, Director of the PPOP. Through the training program, Dr. Stafford will: 1) develop and apply a systematic approach to mentoring that supplements the traditional apprenticeship model with a variety of other educational and career building experiences. These skills are required for a career in patient-oriented research, but are often overlooked;2) Through salary support and the availability of mentoring time, increase Dr. Stafford's capacity to provide a greater depth of mentoring to a larger number of mentees;3) address current problems with the poor translation of scientific knowledge into widespread practice by involving mentees in research projects aimed at increasing the adoption of recommended heart disease guidelines in health care systems. Working closely with Dr. Stafford and PPOP research analysts, innovative educational and career building experiences for the mentees in this program will include: assisting in clinical trial design including recruitment strategies, statistical analysis of data, oral presentation of findings, writing research manuscripts, developing their portfolio of projects, developing strategies for the dissemination of research results, and strategic career planning. Trainees being mentored under this award will gain experience in patient-oriented research by training on four research projects: 1) The Stanford and San Mateo County Heart to Heart Project: This ongoing clinical trial will implement and evaluate a case-management approach to cardiac risk factors. 2) An Internet-based Cardiovascular Intervention for the Socioeconomically Disadvantaged: This project will develop and pilot test an internet-based intervention that incorporates educational material and behavioral interventions for cardiovascular disease risk reduction. 3) A Stage-tailored Online Intervention to Reduce Women's Risk for Osteoporotic Fractures: This project will develop and pilot test an Internet-based bone-health intervention. 4) Achieving Lasting Weight Loss through Case-Management and Environmental Support: This project will evaluate, through a randomized clinical trial, the effectiveness of a case- management approach to weight loss with and without a home-based """"""""environmental support"""""""" component. In summary, our enormous investment in basic science research is jeopardized if we fail to develop strategies for bringing basic science knowledge to clinical application and then develop methods of ensuring that effective applications are incorporated into health care systems. This award will help address the second translational """"""""bottleneck"""""""" through a systematic approach to training mentees in the conduct of patient-oriented research aimed at improving the adoption of evidence-based practices.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Special Emphasis Panel (ZHL1-CSR-R (O1))
Program Officer
Czajkowski, Susan
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Stanford University
Internal Medicine/Medicine
Schools of Medicine
United States
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Shah, Shreya J; Stafford, Randall S (2018) Patterns of Systolic Blood Pressure Control in the United States, 2016. J Gen Intern Med 33:1224-1226
Rosas, Lisa G; Vasquez, Jan J; Naderi, Ramin et al. (2016) Development and evaluation of an enhanced diabetes prevention program with psychosocial support for urban American Indians and Alaska natives: A randomized controlled trial. Contemp Clin Trials 50:28-36
Vaz Fragoso, Carlos A; Beavers, Daniel P; Anton, Stephen D et al. (2016) Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations. J Am Geriatr Soc 64:501-9
Newman, Anne B; Dodson, John A; Church, Timothy S et al. (2016) Cardiovascular Events in a Physical Activity Intervention Compared With a Successful Aging Intervention: The LIFE Study Randomized Trial. JAMA Cardiol 1:568-74
Rosas, Lisa Goldman; Thiyagarajan, Sreedevi; Goldstein, Benjamin Alan et al. (2015) The effectiveness of two community-based weight loss strategies among obese, low-income US Latinos. J Acad Nutr Diet 115:537-50.e2
Chung, Sukyung; Zhao, Beinan; Lauderdale, Diane et al. (2015) Initiation of treatment for incident diabetes: evidence from the electronic health records in an ambulatory care setting. Prim Care Diabetes 9:23-30
Drieling, Rebecca Lucia; Goldman Rosas, Lisa; Ma, Jun et al. (2014) Community resource utilization, psychosocial health, and sociodemographic factors associated with diet and physical activity among low-income obese Latino immigrants. J Acad Nutr Diet 114:257-65
Hurley, Michael P; Stafford, Randall S; Lane, Alfred T (2014) Characterizing the relationship between free drug samples and prescription patterns for acne vulgaris and rosacea. JAMA Dermatol 150:487-93
Turner, Lydia W; Nartey, David; Stafford, Randall S et al. (2014) Ambulatory treatment of type 2 diabetes in the U.S., 1997-2012. Diabetes Care 37:985-92
Blonstein, Andrea C; Yank, Veronica; Stafford, Randall S et al. (2013) Translating an evidence-based lifestyle intervention program into primary care: lessons learned. Health Promot Pract 14:491-7

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