Abstract

The applicant proposes to acquire training in functional neuroimaging technology, including fMRI and PET. This will expand her expertise in neuroimaging and psychiatry from the structural realm into the functional neuroanatomic domain, and further her research endeavors in attempting to understand the neuroanatomic underpinnings of psychiatric disorders. The applicant proposes to work extensively with the Brain Mapping Division at UCLA and proposes an fMRI research project to explore brain changes that occur with mood changes in mania and depression. She will look for blood flow changes that occur in the amygdala and frontal lobe as a function of changing mood state. Specifically, she will assess fMRI signal activation in the amygdala and frontal cortex (anterior cingulate, orbitofrontal and lateral prefrontal areas) in bipolar subjects as they go from either mania to euthymia or depression to euthymia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH001848-03
Application #
6651513
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Project Start
2001-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
3
Fiscal Year
2003
Total Cost
$115,768
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Brooks 3rd, J O; Vizueta, N; Penfold, C et al. (2015) Prefrontal hypoactivation during working memory in bipolar II depression. Psychol Med 45:1731-40
Townsend, Jennifer D; Sugar, Catherine A; Walshaw, Patricia D et al. (2013) Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. J Affect Disord 147:389-96
Foland-Ross, Lara C; Thompson, Paul M; Sugar, Catherine A et al. (2013) Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium. Psychiatry Res 211:195-201
Townsend, Jennifer D; Torrisi, Salvatore J; Lieberman, Matthew D et al. (2013) Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 73:127-35
Barysheva, Marina; Jahanshad, Neda; Foland-Ross, Lara et al. (2013) White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study. Neuroimage Clin 2:558-68
Torrisi, Salvatore; Moody, Teena D; Vizueta, Nathalie et al. (2013) Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disord 15:156-66
Townsend, Jennifer D; Bookheimer, Susan Y; Foland-Ross, Lara C et al. (2012) Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task. Bipolar Disord 14:442-50
Foland-Ross, Lara C; Bookheimer, Susan Y; Lieberman, Matthew D et al. (2012) Normal amygdala activation but deficient ventrolateral prefrontal activation in adults with bipolar disorder during euthymia. Neuroimage 59:738-44
Hegarty, Catherine E; Foland-Ross, Lara C; Narr, Katherine L et al. (2012) ADHD comorbidity can matter when assessing cortical thickness abnormalities in patients with bipolar disorder. Bipolar Disord 14:843-55
Strakowski, Stephen M; Adler, Caleb M; Almeida, Jorge et al. (2012) The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord 14:313-25

Showing the most recent 10 out of 23 publications