: As stated in the NIMH Consensus Development Conference on ADHD, there is a clear need to more basically define ADHD using basic research techniques. Despite technological advances in neuroimaging (e.g., fMRI) which allow for more direct examination of neurobiological bases to clinical disorders, few neuroimaging studies have been conducted with ADHD populations. The paucity of clinical imaging studies likely results from a lack of investigators who are sufficiently trained in both clinical psychology and neuroimaging, thus being able to define and study the population of interest. The primary objective of the proposed activities is to enhance my expertise in neuroimaging and to apply this expertise to my established research with ADHD patients. Using time liberated by the proposed award, I plan to further my career development by participating in coursework, """"""""hands-on"""""""" experiences, and mentoring and teaching activities which will enhance both my own and my students/colleagues expertise in state-of-the-art neuroimaging methods and analysis. This plan will accomplish my immediate research and training goals by allowing me to establish myself as a patient-oriented researcher with expertise in clinical neuroimaging. This short-term goal will foster my long-term career interests which center on conducting extensive investigations into the multiple neurobiological correlates (e.g., neuroanatomy, genetics) of ADHD. The study proposed in the research plan will utilize 30 concordantly-affected ADHD parent-child dyads and 15 non-ADHD normal dyads. All dyads will perform a series of neuropsychological tests while generic brain activation is assessed using functional MRI (fMRI). ADHD parent-child dyads will also participate in a repeated measures study examining functional neuroanatomical change in response to stimulant medication. Between-group comparisons will evaluate structural and functional neuroanatomical differences between ADHD and normal parent-child dyads. Within-group analyses will compare ADHD patients functional activation changes across placebo and active medication conditions. In addition, parent-child correspondences in neuropsychological performance, neuroanatomy, and brain activation will be examined within the two groups of dyads.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH064478-02
Application #
6620311
Study Section
Special Emphasis Panel (ZRG1-BBBP-6 (01))
Program Officer
Rumsey, Judith M
Project Start
2001-12-14
Project End
2006-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
2
Fiscal Year
2003
Total Cost
$93,270
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Brinkman, William B; Simon, John O; Epstein, Jeffery N (2018) Reasons Why Children and Adolescents With Attention-Deficit/Hyperactivity Disorder Stop and Restart Taking Medicine. Acad Pediatr 18:273-280
Narad, Megan E; Garner, Annie A; Antonini, Tanya N et al. (2018) Negative Consequences of Poor Driving Outcomes Reported by Adolescents With and Without ADHD. J Atten Disord 22:1109-1112
Al Ghriwati, Nour; Langberg, Joshua M; Gardner, William et al. (2017) Impact of Mental Health Comorbidities on the Community-Based Pediatric Treatment and Outcomes of Children with Attention Deficit Hyperactivity Disorder. J Dev Behav Pediatr 38:20-28
Garner, Annie A; Peugh, James; Becker, Stephen P et al. (2017) Does Sluggish Cognitive Tempo Fit Within a Bi-Factor Model of ADHD? J Atten Disord 21:642-654
Epstein, Jeffery N; Kelleher, Kelly J; Baum, Rebecca et al. (2017) Specific Components of Pediatricians' Medication-Related Care Predict Attention-Deficit/Hyperactivity Disorder Symptom Improvement. J Am Acad Child Adolesc Psychiatry 56:483-490.e1
Becker, Stephen P; Ciesielski, Heather A; Rood, Jennifer E et al. (2016) Uncovering a clinical portrait of sluggish cognitive tempo within an evaluation for attention-deficit/hyperactivity disorder: A case study. Clin Child Psychol Psychiatry 21:81-94
Brinkman, William B; Baum, Rebecca; Kelleher, Kelly J et al. (2016) Relationship Between Attention-Deficit/Hyperactivity Disorder Care and Medication Continuity. J Am Acad Child Adolesc Psychiatry 55:289-94
Tewar, Shruti; Auinger, Peggy; Braun, Joseph M et al. (2016) Association of Bisphenol A exposure and Attention-Deficit/Hyperactivity Disorder in a national sample of U.S. children. Environ Res 150:112-118
Tamm, Leanne; Garner, Annie A; Loren, Richard E A et al. (2016) Slow sluggish cognitive tempo symptoms are associated with poorer academic performance in children with ADHD. Psychiatry Res 242:251-259
Epstein, Jeffery N; Kelleher, Kelly J; Baum, Rebecca et al. (2016) Impact of a Web-Portal Intervention on Community ADHD Care and Outcomes. Pediatrics 138:

Showing the most recent 10 out of 53 publications