The Candidate: This is a resubmission of a K24 for Dr. Kristin Cadenhead, an Associate Professor of Psychiatry, who has been committed to performing Patient Oriented Research in the schizophrenia spectrum of disorders since her psychiatry residency. Throughout her research career, Dr. Cadenhead has provided training and mentorship to undergraduate and graduate students, psychiatry residents, post- doctoral fellows and clinical faculty while performing high quality clinical research. In addition to research, Dr. Cadenhead serves as Director of the Psychiatry Primary Care Clinic at the VA, a teaching service for psychiatry residents, and as an Associate Residency Training Director. Environment: The Department of Psychiatry at UCSD has been a leader in the scientific and academic community since its inception and is devoted to recruiting and retaining some of the most outstanding scientists in the field. Trainees in the department receive training from scientists performing cutting edge research and many become the leaders of the future. Funded Research: The Cognitive Assessment and Risk Evaluation (CARE) Program has been a highly successful research program funded by a recently renewed R01, """"""""Vulnerability Markers in Prodromal Schizophrenia"""""""" (MH60720), that is anticipated to be an ongoing resource for longitudinal studies. The CARE program is unique in that it combines the current knowledge of clinical and demographic risk factors for schizophrenia with the rapidly emerging data on vulnerability markers, or endophenotypes, that are associated with schizophrenia. New Research: We propose to add a mismatch negativity paradigm to our psychophysiological battery as a prelude to future collaborative projects. Career goals: To build on the strong foundation that has been established to make a greater impact on the emerging research into the prodrome of schizophrenia. One fourth of Dr. Cadenhead's effort will be devoted to mentoring clinical investigators and developing collabortative relationships at UCSD and nationwide. Relevance: The use of brain-based vulnerability markers may help to identify neurobiologically and clinically meaningful subgroups that are at increased risk for psychosis. Earlier identification and more accurate prediction of risk can lead to appropriate intervention at an early stage that could possibly prevent or delay the development of a psychotic illness along with clinical and functional deterioration. ? ? ?
| Hampton, Joya N; Trotman, Hanan D; Addington, Jean et al. (2018) The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis. Stress Health 34:591-600 |
| Kline, Emily R; Seidman, Larry J; Cornblatt, Barbara A et al. (2018) Depression and clinical high-risk states: Baseline presentation of depressed vs. non-depressed participants in the NAPLS-2 cohort. Schizophr Res 192:357-363 |
| Velthorst, Eva; Meyer, Eric C; Giuliano, Anthony J et al. (2018) Neurocognitive profiles in the prodrome to psychosis in NAPLS-1. Schizophr Res : |
| Lu, Yun; Marshall, Catherine; Cadenhead, Kristin S et al. (2017) Perceptual abnormalities in clinical high risk youth and the role of trauma, cannabis use and anxiety. Psychiatry Res 258:462-468 |
| Addington, Jean; Piskulic, Danijela; Liu, Lu et al. (2017) Comorbid diagnoses for youth at clinical high risk of psychosis. Schizophr Res 190:90-95 |
| McAusland, Laina; Buchy, Lisa; Cadenhead, Kristin S et al. (2017) Anxiety in youth at clinical high risk for psychosis. Early Interv Psychiatry 11:480-487 |
| Marshall, Catherine; Lu, Yun; Lyngberg, Kristina et al. (2017) Changes in symptom content from a clinical high-risk state to conversion to psychosis. Early Interv Psychiatry : |
| Deighton, Stephanie; Buchy, Lisa; Cadenhead, Kristin S et al. (2016) Traumatic brain injury in individuals at clinical high risk for psychosis. Schizophr Res 174:77-81 |
| McLaughlin, Danielle; Carrión, Ricardo E; Auther, Andrea M et al. (2016) Functional Capacity Assessed by the Map Task in Individuals at Clinical High-Risk for Psychosis. Schizophr Bull 42:1234-42 |
| Stowkowy, Jacqueline; Liu, Lu; Cadenhead, Kristin S et al. (2016) Early traumatic experiences, perceived discrimination and conversion to psychosis in those at clinical high risk for psychosis. Soc Psychiatry Psychiatr Epidemiol 51:497-503 |
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