This is an application for a Mid-Career Investigator Award in Patient Oriented Research (K24) for J. Douglas Bremner, M.D., to enhance his research career and to allow him to provide mentoring to junior investigators in the area of biological correlates of traumatic stress. Studies by the applicant have applied brain imaging to the study of posttraumatic stress disorder (PTSD), using magnetic resonance imaging (MRI) to show smaller hippocampal volume in PTSD, and positron emission tomography (PET) to show alterations in a neural circuit involving medial prefrontal cortex, hippocampus and amygdala in PTSD. Other studies by the applicant applied animal findings showing that serotonin reuptake inhibitors (SSRIs) promote neurogenesis (which is inhibited by stress) to show that SSRIs result in a 5% increase in hippocampal volume and 30% improvement in hippocampal-based declarative memory function. Current studies are using fMRI to study neural correlates of a word list learning paradigm and recall of traumatic memories with a history of early abuse. The applicant has been very productive in performing research and in recent years has had an increase in the number of senior author publications; he now would like to change focus and spend more time mentoring junior faculty and trainees. The Training Program in Neuroimaging Sciences (TPINS), Graduate Program in Neuroscience at Emory, and other resources, including the Center for Disease Control (CDC), Center for Behavioral Neuroscience, and Yerkes Regional Primate Center, represent excellent opportunities for research and the development of trainees. There is a collegial and collaborative atmosphere at Emory that creates as excellent experience for trainees. Emory University has the highest proportion of minority students and faculty of any of the top 25 universities in the US, offering an excellent opportunity for training in an area particularly relevant for minorities. The mentoring provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH076955-02
Application #
7226642
Study Section
Special Emphasis Panel (ZRG1-BBBP-L (02))
Program Officer
Meinecke, Douglas L
Project Start
2006-05-01
Project End
2011-04-30
Budget Start
2007-05-03
Budget End
2008-04-30
Support Year
2
Fiscal Year
2007
Total Cost
$124,700
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Sullivan, Samaah; Kelli, Heval M; Hammadah, Muhammad et al. (2018) Neighborhood poverty and hemodynamic, neuroendocrine, and immune response to acute stress among patients with coronary artery disease. Psychoneuroendocrinology 100:145-155
Huang, Yunfeng; Hui, Qin; Walker, Douglas I et al. (2018) Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation. Epigenomics 10:379-393
Hammadah, Muhammad; Sullivan, Samaah; Pearce, Brad et al. (2018) Inflammatory response to mental stress and mental stress induced myocardial ischemia. Brain Behav Immun 68:90-97
Vaccarino, Viola; Sullivan, Samaah; Hammadah, Muhammad et al. (2018) Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences and Mechanisms. Circulation 137:794-805
Pimple, Pratik; Hammadah, Muhammad; Wilmot, Kobina et al. (2018) Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences. Am J Med 131:540-547.e1
Sullivan, Samaah; Hammadah, Muhammad; Al Mheid, Ibhar et al. (2018) Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress. Arterioscler Thromb Vasc Biol 38:473-480
Bremner, J Douglas; Campanella, Carolina; Khan, Zehra et al. (2018) Brain Correlates of Mental Stress-Induced Myocardial Ischemia. Psychosom Med 80:515-525
Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2018) Association Between High-Sensitivity Cardiac Troponin Levels and Myocardial Ischemia During Mental Stress and Conventional Stress. JACC Cardiovasc Imaging 11:603-611
Vaccarino, Viola; Bremner, J Douglas (2017) Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women. Neurosci Biobehav Rev 74:297-309
O'Neal, Wesley T; Hammadah, Muhammad; Sandesara, Pratik B et al. (2017) The association between acute mental stress and abnormal left atrial electrophysiology. J Cardiovasc Electrophysiol 28:1151-1157

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