This is an application for a Mid-Career Investigator Award in Patient Oriented Research (K24) for J. Douglas Bremner, M.D., to enhance his research career and to allow him to provide mentoring to junior investigators in the area of biological correlates of traumatic stress. Studies by the applicant have applied brain imaging to the study of posttraumatic stress disorder (PTSD), using magnetic resonance imaging (MRI) to show smaller hippocampal volume in PTSD, and positron emission tomography (PET) to show alterations in a neural circuit involving medial prefrontal cortex, hippocampus and amygdala in PTSD. Other studies by the applicant applied animal findings showing that serotonin reuptake inhibitors (SSRIs) promote neurogenesis (which is inhibited by stress) to show that SSRIs result in a 5% increase in hippocampal volume and 30% improvement in hippocampal-based declarative memory function. Current studies are using fMRI to study neural correlates of a word list learning paradigm and recall of traumatic memories with a history of early abuse. The applicant has been very productive in performing research and in recent years has had an increase in the number of senior author publications;he now would like to change focus and spend more time mentoring junior faculty and trainees. The Training Program in Neuroimaging Sciences (TPINS), Graduate Program in Neuroscience at Emory, and other resources, including the Center for Disease Control (CDC), Center for Behavioral Neuroscience, and Yerkes Regional Primate Center, represent excellent opportunities for research and the development of trainees. There is a collegial and collaborative atmosphere at Emory that creates as excellent experience for trainees. Emory University has the highest proportion of minority students and faculty of any of the top 25 universities in the US, offering an excellent opportunity for training in an area particularly relevant for minorities. The mentoring provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH076955-05
Application #
7840496
Study Section
Special Emphasis Panel (ZRG1-BBBP-L (02))
Program Officer
Rumsey, Judith M
Project Start
2006-05-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2012-04-30
Support Year
5
Fiscal Year
2010
Total Cost
$133,659
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Vaccarino, Viola; Bremner, J Douglas (2017) Behavioral, emotional and neurobiological determinants of coronary heart disease risk in women. Neurosci Biobehav Rev 74:297-309
Bremner, James Douglas; Mishra, Sanskriti; Campanella, Carolina et al. (2017) A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Str Front Psychiatry 8:157
Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) The Mental Stress Ischemia Prognosis Study: Objectives, Study Design, and Prevalence of Inducible Ischemia. Psychosom Med 79:311-317
Sullivan, Samaah; Hammadah, Muhammad; Al Mheid, Ibhar et al. (2017) Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress. Arterioscler Thromb Vasc Biol :
Hammadah, Muhammad; Alkhoder, Ayman; Al Mheid, Ibhar et al. (2017) Hemodynamic, catecholamine, vasomotor and vascular responses: Determinants of myocardial ischemia during mental stress. Int J Cardiol 243:47-53
Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) Telomere Shortening, Regenerative Capacity, and Cardiovascular Outcomes. Circ Res 120:1130-1138
O'Neal, Wesley T; Hammadah, Muhammad; Sandesara, Pratik B et al. (2017) The association between acute mental stress and abnormal left atrial electrophysiology. J Cardiovasc Electrophysiol 28:1151-1157
Klebaner, Daniella; Huang, Yunfeng; Hui, Qin et al. (2016) X chromosome-wide analysis identifies DNA methylation sites influenced by cigarette smoking. Clin Epigenetics 8:20
Rooks, Cherie R; Ibeanu, Ijeoma; Shah, Amit et al. (2016) Young women post-MI have higher plasma concentrations of interleukin-6 before and after stress testing. Brain Behav Immun 51:92-8
Pimple, Pratik; Shah, Amit; Rooks, Cherie et al. (2015) Association between anger and mental stress-induced myocardial ischemia. Am Heart J 169:115-21.e2

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