The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs;and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD;and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research; and 2) provide excellent opportunities for mentoring clinician-investigators.

Public Health Relevance

This is a grant application for a Midcareer Investigator Award in Patient-Oriented Research (K24) to enable Dr. Helen Blair Simpson to advance her capacity to conduct patient-oriented research and to enhance her ability to mentor clinician-investigators who seek to conduct patient-oriented research. The application is based on the candidate's interdisciplinary program focused on obsessive-compulsive disorder (OCD). It proposes a focused training program for the candidate, a plan for mentoring clinician-investigators in patient-oriented research, and a pilot project to identify biomarkers/behavioral indicators for OCD, an objective of the NIMH strategic plan.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-F (08))
Program Officer
Meinecke, Douglas L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Columbia University (N.Y.)
Schools of Medicine
New York
United States
Zip Code
Posner, Jonathan; Song, Inkyung; Lee, Seonjoo et al. (2017) Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp 38:678-687
Patel, Sapana R; Galfavy, Hanga; Kimeldorf, Marcia B et al. (2017) Patient Preferences and Acceptability of Evidence-Based and Novel Treatments for Obsessive-Compulsive Disorder. Psychiatr Serv 68:250-257
Kalanthroff, Eyal; Teichert, Tobias; Wheaton, Michael G et al. (2017) The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task. Depress Anxiety 34:301-306
Schneier, Franklin R; Kimeldorf, Marcia B; Choo, Tse Hwei et al. (2016) Attention bias in adults with anorexia nervosa, obsessive-compulsive disorder, and social anxiety disorder. J Psychiatr Res 79:61-69
Kalanthroff, Eyal; Linkovski, Omer; Weinbach, Noam et al. (2016) What underlies the effect of sleep disruption? The role of alertness in obsessive-compulsive disorder (OCD). J Behav Ther Exp Psychiatry :
Rodriguez, Carolyn I; Zwerling, Jordana; Kalanthroff, Eyal et al. (2016) Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept. Am J Psychiatry 173:1239-1241
Wheaton, Michael G; Carpenter, Joseph K; Kalanthroff, Eyal et al. (2016) Augmenting SRIs for Obsessive-Compulsive Disorder: Patient Preference for Risperidone Does Not Limit Effectiveness of Exposure and Ritual Prevention. Psychother Psychosom 85:314-6
Rodriguez, Carolyn I; Levinson, Amanda; Zwerling, Jordana et al. (2016) Open-Label trial on the effects of memantine in adults with obsessive-compulsive disorder after a single ketamine infusion. J Clin Psychiatry 77:688-9
Rodriguez, Carolyn I; Wheaton, Michael; Zwerling, Jordana et al. (2016) Can exposure-based CBT extend the effects of intravenous ketamine in obsessive-compulsive disorder? an open-label trial. J Clin Psychiatry 77:408-9
Leonard, Rachel C; Franklin, Martin E; Wetterneck, Chad T et al. (2016) Residential treatment outcomes for adolescents with obsessive-compulsive disorder. Psychother Res 26:727-36

Showing the most recent 10 out of 53 publications