This k24 is an application for mentoring junior investigators in behavioral interventions related to HIV treatment and prevention, specifically focusing on associated psychosocial syndemics relevant to HIV prevention and care. Mental health problems, including substance abuse, are of the most frequent comorbidities to HIV and are consistently identified as barriers to adherence, engagement in care, and reductions in risk behavior. Typically these problems co-occur as """"""""syndemics"""""""" (co-occurring psychosocial problems that interact with each other and with HIV risk). Candidate. The candidate has over 10 years of NIH-funded support addressing mental health, substance abuse, and psychosocial comorbidities in the context of interventions for HIV/AIDS. This includes interventions for depression and adherence in HIV, domestic and international primary and secondary prevention studies, and mentee projects addressing various syndemic indicators and HIV prevention in men who have sex with men (MSM). The candidate also has a strong and consistent successful mentoring history, including over 30 fellows and junior faculty, resulting in >60 publications with mentees as first author. Mentoring Plan/Environment. The candidate is Director of Behavioral Medicine in the Department of Psychiatry at Massachusetts General Hospital (MGH) / Harvard Medical School (HMS), Co-Director of the Harvard University Behavioral Sciences Program for the CFAR, and an affiliated faculty at Fenway Health. In these roles, the candidate has been receiving increasing and multiple requests to mentor junior level clinical researchers across disciplines. He has access to psychology / behavioral medicine mentees generally from the MGH clinical psychology training program, access to local physician and public health mentees through the Harvard University CFAR, which stems all of the Harvard Hospitals, additional local hospitals (e.g. Shattuck Hospital) the Harvard School of Public Health, and Harvard programs. He also is receiving increasing requests to mentor national and international colleagues in behavioral science methods through the CFAR and NIAID CTU networks and other sources. These emerging and established scientist mentees typically require mentoring in behavioral intervention development and testing, including incorporating behavioral science into biomedical or epidemiological science projects. The current project will allow him to accommodate and grow these requests through protected time for mentoring. Research Plan. The candidate's depression/adherence studies in HIV, although successful in treating depression and improving adherence, to date have found exceptionally high levels of comorbidity in patients with HIV and depression. This has raised the need to address other syndemics (e.g. substance abuse, PTSD, other anxiety disorders) in addition to depression in the context of care. As a platform for mentee involvement in research, the candidate will leverage his existing R01 on treating depression in HIV, to begin to learn how to best treat the most frequent syndemics with HIV, in the context of improving health-related behavior change.

Public Health Relevance

Psychiatric comorbidity with HIV infection is exceptionally high, and is likely one of the biggest barriers to consistent self-care behavior. Behavioral science prevention and treatment interventions related to HIV/AIDS have not typically focused on incorporating the treatment of syndemics into interventions for health-related behavior change, though these problems likely moderate the degree to which behavioral interventions for individuals with HIV can be successful. The candidate has been receiving increasing requests for mentoring in this area, has a strong history of HIV prevention and treatment research related to mental health and substance abuse comorbidities, is situated in a highly furtive environment for selecting mentees to address these public health problems, and needs protected time to meet and expand mentoring activities.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Midcareer Investigator Award in Patient-Oriented Research (K24)
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Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stirratt, Michael J
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Massachusetts General Hospital
United States
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Biello, Katie B; Oldenburg, Catherine E; Mitty, Jennifer A et al. (2017) The ""Safe Sex"" Conundrum: Anticipated Stigma From Sexual Partners as a Barrier to PrEP Use Among Substance Using MSM Engaging in Transactional Sex. AIDS Behav 21:300-306
Khidir, Hazar; Psaros, Christina; Greener, Letitia et al. (2017) Developing a Safer Conception Intervention for Men Living with HIV in South Africa. AIDS Behav :
Oldenburg, Catherine E; Mitty, Jennifer A; Biello, Katie B et al. (2016) Differences in Attitudes About HIV Pre-Exposure Prophylaxis Use Among Stimulant Versus Alcohol Using Men Who Have Sex with Men. AIDS Behav 20:1451-60
Magidson, Jessica F; Li, Xin; Mimiaga, Matthew J et al. (2016) Antiretroviral Medication Adherence and Amplified HIV Transmission Risk Among Sexually Active HIV-Infected Individuals in Three Diverse International Settings. AIDS Behav 20:699-709
Dale, Sannisha K; Traeger, Lara; O'Cleirigh, Conall et al. (2016) Baseline Substance Use Interferes with Maintenance of HIV Medication Adherence Skills. AIDS Patient Care STDS 30:215-20
Blashill, Aaron J; Tomassilli, Julia; Biello, Katie et al. (2016) Body Dissatisfaction Among Sexual Minority Men: Psychological and Sexual Health Outcomes. Arch Sex Behav 45:1241-7
Perry, Nicholas S; Wade Taylor, S; Elsesser, Steven et al. (2016) The Predominant Relationship Between Sexual Environment Characteristics and HIV-Serodiscordant Condomless Anal Sex Among HIV-Positive Men Who Have Sex with Men (MSM). AIDS Behav 20:1228-35
Duncan, Dustin T; Goedel, William C; Mayer, Kenneth H et al. (2016) Poor sleep health and its association with mental health, substance use, and condomless anal intercourse among gay, bisexual, and other men who have sex with men. Sleep Health 2:316-321
Magidson, Jessica F; Stevenson, Anne; Ng, Lauren C et al. (2016) Massachusetts General Hospital Global Psychiatric Clinical Research Training Program: A New Fellowship in Global Mental Health. Acad Psychiatry 40:695-7
Stack, Conor; Oldenburg, Catie; Mimiaga, Matthew et al. (2016) Sexual Behavior Patterns and PrEP Dosing Preferences in a Large Sample of North American Men Who Have Sex With Men. J Acquir Immune Defic Syndr 71:94-101

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