HIV+ patients are aging, due in large part to the successes of combination antiretroviral medications. Despite these accomplishments, over 50% of community dwelling HIV+ patients have cognitive impairment, a frequency that increases with age. The candidate of this application has developed a robust clinical research environment to address brain vulnerability in the setting of HIV. His training in internal medicine, geriatric medicine and neurobehavior allow him to link disciplines and inform the cognitive consequences of aging with HIV. The work proposed in this application will enhance and stabilize his career development to focus more directly on training the next generation of high quality patient-oriented researchers. The proposed science will focus on the functional consequence of cognitive impairment in HIV over age 60 and the co-existence of geriatric syndromes. Unique features of the mentoring plan include access to networks of patients, a passion for training early-stage investigators, and the multi-disciplinary training of the candidate.

Public Health Relevance

The work proposed in this application will train the next generation of clinician researchers in geriatric and cognitive science as it relates to HIV. This s critically important as the population of HIV+ patients in the US ages so that optimal health outcomes can be achieved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24MH098759-02
Application #
8593316
Study Section
Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
Program Officer
Stoff, David M
Project Start
2012-12-06
Project End
2017-11-30
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
2
Fiscal Year
2014
Total Cost
$178,528
Indirect Cost
$13,224
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Clifford, Katherine M; Samboju, Vishal; Cobigo, Yann et al. (2017) Progressive Brain Atrophy Despite Persistent Viral Suppression in HIV Patients Older Than 60 Years. J Acquir Immune Defic Syndr 76:289-297
Imp, Brandon M; Rubin, Leah H; Tien, Phyllis C et al. (2017) Monocyte Activation Is Associated With Worse Cognitive Performance in HIV-Infected Women With Virologic Suppression. J Infect Dis 215:114-121
Valcour, Victor G; Rubin, Leah H; Obasi, Mary U et al. (2016) Liver Fibrosis Linked to Cognitive Performance in HIV and Hepatitis C. J Acquir Immune Defic Syndr 72:266-73
Zhang, Yong; Kwon, Dongjin; Esmaeili-Firidouni, Pardis et al. (2016) Extracting patterns of morphometry distinguishing HIV associated neurodegeneration from mild cognitive impairment via group cardinality constrained classification. Hum Brain Mapp 37:4523-4538
Wendelken, Lauren A; Jahanshad, Neda; Rosen, Howard J et al. (2016) ApoE ?4 Is Associated With Cognition, Brain Integrity, and Atrophy in HIV Over Age 60. J Acquir Immune Defic Syndr 73:426-432
Hellmuth, Joanna; Fletcher, James L K; Valcour, Victor et al. (2016) Neurologic signs and symptoms frequently manifest in acute HIV infection. Neurology 87:148-54
Chan, Phillip; Hellmuth, Joanna; Spudich, Serena et al. (2016) Cognitive Impairment and Persistent CNS Injury in Treated HIV. Curr HIV/AIDS Rep 13:209-17
Guha, Anika; Wang, Liang; Tanenbaum, Aaron et al. (2016) Intrinsic network connectivity abnormalities in HIV-infected individuals over age 60. J Neurovirol 22:80-7
Wade, Benjamin S C; Valcour, Victor G; Wendelken-Riegelhaupt, Lauren et al. (2015) Mapping abnormal subcortical brain morphometry in an elderly HIV+ cohort. Neuroimage Clin 9:564-73
Maki, Pauline M; Rubin, Leah H; Valcour, Victor et al. (2015) Cognitive function in women with HIV: findings from the Women's Interagency HIV Study. Neurology 84:231-40

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