Nearly 46% of women and 33% of men report attempts to lose weight. However, weight cycling - intentional weight loss followed by regain of at least 10Ibs. - occurs in approximately 80% of adults who lose weight;50% of the weight regain occurs within a year. A major focus of the candidate's research is on behavioral and technological strategies to improve long-term weight loss maintenance. With the support of the Midcareer Investigator Award in Patient-Oriented Research (K24), the candidate will expand this focus to an investigation of the biobehavioral processes involved in the failure to maintain a loss and the subsequent weight regain. The proposed study will build on an ongoing randomized clinical trial (SMART study) and collect specimens every 6 months during the 24-month behavioral, weight loss intervention so that the candidate and her multidisciplinary team can prospectively study the subset of individuals who lose and regain at least 10Ibs. during the study. The study's 3 aims are: (1) describe the patterns of weight loss and regain from baseline to 24 months and their effect on insulin resistance (plasma insulin), adipokines (TNFalpha, IL-6, adiponectin, IL-10), and ghrelin and leptin;(2) describe the behaviors related to energy intake and energy expenditure and explore their temporal associations with weight loss and weight gain;and (3) explore whether variation in genes implicated in weight change are related to change in serum level of adipokines and to the behaviors related to weight loss and regain. The mentorship plan will focus on the candidate (PI) and a multidisciplinary cadre of mentees who have been working with her. With the support of the K24 Award, Dr. Burke will work with an interdisciplinary team to advance her knowledge of the inflammatory processes that may occur with weight regain, which may provide the link between obesity, insulin resistance, atherosclerosis and cardiovascular disease;additionally, she will focus on the possible role of genetics in these biobehavioral processes. She will use her ongoing studies to mentor students, fellows and junior faculty on the development of behavioral interventions, the use of technology in interventions and measurement, the conduct of clinical trials, and the role of inflammation and genetics in weight loss and regain. She will develop a mentoring program that follows NINR's strategies for integrating biological and behavioral science for better health, and adopting new technologies for better health care. The proposed study and mentoring strategies will be placed in the context of an area of NINR emphasis - promoting health and preventing disease as it addresses a highly prevalent chronic disorder - overweight and obesity.

National Institute of Health (NIH)
National Institute of Nursing Research (NINR)
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
Application #
Study Section
National Institute of Nursing Research Initial Review Group (NRRC)
Program Officer
Cotton, Paul
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Nursing
United States
Zip Code
Zheng, Yaguang; Sereika, Susan M; Ewing, Linda J et al. (2016) Association between Self-Weighing and Percent Weight Change: Mediation Effects of Adherence to Energy Intake and Expenditure Goals. J Acad Nutr Diet 116:660-6
Ye, Lei; Youk, Ada O; Sereika, Susan M et al. (2016) A three-step estimation procedure using local polynomial smoothing for inconsistently sampled longitudinal data. Stat Med 35:3613-22
Goode, Rachel W; Ye, Lei; Sereika, Susan M et al. (2016) Socio-demographic, anthropometric, and psychosocial predictors of attrition across behavioral weight-loss trials. Eat Behav 20:27-33
Wang, Jing; Ye, Lei; Zheng, Yaguang et al. (2015) Impact of Perceived Barriers to Healthy Eating on Diet and Weight in a 24-Month Behavioral Weight Loss Trial. J Nutr Educ Behav 47:432-6.e1
Burke, Lora E; Ewing, Linda J; Ye, Lei et al. (2015) The SELF trial: A self-efficacy-based behavioral intervention trial for weight loss maintenance. Obesity (Silver Spring) 23:2175-82
Ambeba, Erica J; Ye, Lei; Sereika, Susan M et al. (2015) The use of mHealth to deliver tailored messages reduces reported energy and fat intake. J Cardiovasc Nurs 30:35-43
Zheng, Yaguang; Terhorst, Lauren; Choo, Jina et al. (2014) Psychometric properties of the Perceived Therapeutic Efficacy Scale for adhering to a cholesterol-lowering diet. J Cardiovasc Nurs 29:257-63
Linkov, Faina; Burke, Lora E; Komaroff, Marina et al. (2014) An exploratory investigation of links between changes in adipokines and quality of life in individuals undergoing weight loss interventions: possible implications for cancer research. Gynecol Oncol 133:67-72
Wang, Jing; Sereika, Susan M; Styn, Mindi A et al. (2013) Factors associated with health-related quality of life among overweight or obese adults. J Clin Nurs 22:2172-82
Wang, Jing; Matthews, Judith T; Sereika, Susan M et al. (2013) Psychometric Evaluation of the Social Problem-Solving Inventory- Revised among Overweight or Obese Adults. J Psychoeduc Assess 3:585-590

Showing the most recent 10 out of 23 publications