Michael Rowbotham, a clinical neurologist and clinical neuroscientist specializing in chronic pain, has an international reputation as a leader in patient-oriented research on neuropathic pain mechanisms and clinical analgesic trials. The UCSF Pain Clinical Research Center (PCRC), started by Dr. Rowbotham in 1990, is a clinical research unit located in University-owned space that receives NIH, private, and industry support for exploratory clinical research and clinical trials. As a PI in the NINDS Program Project on Pain Mechanisms at UCSF, clinical research that translates advances from the Program's four basic science labs is fostered. Dr. Rowbotham has mentored 15 beginning clinical scientists from diverse backgrounds in the PCRC, and is developing a unique two year research/clinical training program that brings together the PCRC, the Neurology Pain Research Training Grant, and the Anesthesia-Pain Management Center Fellowship. K-24 support for a 5 year period will assist Dr. Rowbotham achieve his long-term career goal of establishing an integrated clinical research program that: (1) has a comprehensive pain research training curriculum for beginning clinical investigators; (2) conducts exploratory clinical research on pain mechanisms underlying different neuropathic pain disorders; (3) uses experimental pain models to evaluate new analgesics in healthy volunteers and patients, (4) translates basic science advances into well designed clinical trials to advance pain therapy; (5) relates pain mechanisms to opioid sensitivity, tolerance, and long term efficacy. The experiments in Project I will: (a) determine if opioid-insensitive chronic pains exist by simultaneously measuring the response of experimentally induced pain and ongoing clinical pain to i.v. remifentanil infusion; (b) determine if a prolonged i.v. remifentanil infusion can produce acute analgesic tolerance to both the experimentally induced pain and hyperalgesia and the ongoing chronic pain; and (c) prospectively assess development of opioid analgesic tolerance during long term oral opioid therapy. Project II will test the hypothesis that development of chronic post-herpetic neuralgia after herpes zoster strongly depends on the severity of the initial neural injury and the quality of neural recovery. Patients with acute zoster pain will be followed for 6 months on measures of pain intensity, mood, quality of life, allodynia, extent of affected skin, quantitative tests of sensory function, response to controlled applications of capsaicin, and serial skin punch biopsy measurement of cutaneous innervation in affected and normal skin.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24NS002164-04
Application #
6639330
Study Section
NST-2 Subcommittee (NST)
Program Officer
Porter, Linda L
Project Start
2000-06-28
Project End
2005-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
4
Fiscal Year
2003
Total Cost
$117,175
Indirect Cost
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Reda, Haatem; Greene, Kaitlin; Rice, Frank L et al. (2013) Natural history of herpes zoster: late follow-up of 3.9 years (n=43) and 7.7 years (n=10). Pain 154:2227-33
Petersen, Karin Lottrup; Rice, Frank L; Farhadi, Mahkam et al. (2010) Natural history of cutaneous innervation following herpes zoster. Pain 150:75-82
Petersen, Karin L; Rowbotham, Michael C (2010) Natural history of sensory function after herpes zoster. Pain 150:83-92
Thyregod, Hans Gustav; Rowbotham, Michael C; Peters, Michelle et al. (2007) Natural history of pain following herpes zoster. Pain 128:148-56
Frymoyer, Adam R; Rowbotham, Michael C; Petersen, Karin Lottrup (2007) Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. J Pain 8:19-25
Abrams, D I; Jay, C A; Shade, S B et al. (2007) Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology 68:515-21
Rowbotham, Michael C; Reisner, Lori A; Davies, Pamela S et al. (2005) Treatment response in antidepressant-naive postherpetic neuralgia patients: double-blind, randomized trial. J Pain 6:741-6
Rowbotham, Michael C; Twilling, Lisa; Davies, Pamela S et al. (2003) Oral opioid therapy for chronic peripheral and central neuropathic pain. N Engl J Med 348:1223-32
Rowbotham, Michael C; Manville, Nira S; Ren, Junlong (2003) Pilot tolerability and effectiveness study of levetiracetam for postherpetic neuralgia. Neurology 61:866-7
Petersen, Karin L; Maloney, Alan; Hoke, Frank et al. (2003) A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. J Pain 4:400-6

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