The candidate proposes a multifaceted mentoring, career development, and research plan in patient- oriented research (POR) on genetic determinants of unexplained phenotypes of subclinical carotid atherosclerosis with the goal of future prevention of stroke. This plan will build on the candidate's established strengths in assessment of carotid ultrasound imaging markers, epidemiology, and current genetic project. This proposal will provide opportunities for junior trainees to obtain training in POR. The K24 award will allow for protected time so that the candidate can devote 90% of her professional effort towards mentoring and developing a formal mentorship program for residents and fellows (The Resident and Fellow Clinician Researcher Program in Neurology) and other trainees, and towards her research and career development in genetic epidemiology. The mentorship program will include (1) Didactic lectures on research methodology, epidemiology, analytical methods, genetics, and scientific writing;(2) Organizing research meetings, seminars, and conferences;(3) Helping trainees to develop their research projects;and (4) One-on-one mentoring. This K24 award will include professional and research career development for the candidate to gain new knowledge and skills in genetic epidemiology. The candidate ongoing POR on the candidate genes and subclinical carotid atherosclerosis will serve as a background for the primary aims of the proposed research to (1) identify individuals with unexplained subclinical atherosclerosis (USA) and unexplained protection against atherosclerosis (UPA) by generating residual scores in the multivariable regression model of subclinical carotid phenotypes fitted from the traditional vascular risk factors;(2) identify alleles associated with USA and UPA by performing a genome wide association study;and (3) assess the 3- year change in carotid plaque burden and identify alleles associated with this change in the sample of UPA and USA. This K24 award will help achieving the candidate's long-term goals in enhancing POR, establishing formal POR mentorship program, providing resources to perform independent research ideas for trainees, and creating an inspiring intellectual environment needed to increase the number of physician-scientists capable of carrying out modern and rigorous POR in neurology. 1

Public Health Relevance

Stroke is a leading cause of death and disability. This project is designed to discover new genetic determinants of subclinical atherosclerosis, a precursor of stroke, and to mentor young trainees in research. Finding genetic markers for precursors of stroke would lead to early identification of persons at high risk for stroke through genetic screening. These findings would improve stroke prevention, which is of great public health importance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24NS062737-04
Application #
8325146
Study Section
Special Emphasis Panel (ZNS1-SRB-M (71))
Program Officer
Gwinn, Katrina
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$199,501
Indirect Cost
$14,778
Name
University of Miami School of Medicine
Department
Neurology
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
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Gardener, Hannah; Monteith, Teshamae; Rundek, Tatjana et al. (2016) Hypertension and Migraine in the Northern Manhattan Study. Ethn Dis 26:323-30
Wright, Clinton B; Shah, Nirav H; Mendez, Armando J et al. (2016) Fibroblast Growth Factor 23 Is Associated With Subclinical Cerebrovascular Damage: The Northern Manhattan Study. Stroke 47:923-8
Tiozzo, Eduard; Gardener, Hannah; Hudson, Barry I et al. (2016) Subfractions of High-Density Lipoprotein-Cholesterol and Carotid Intima-Media Thickness: The Northern Manhattan Study. Stroke 47:1508-13
Gutierrez, Jose; Elkind, Mitchell S V; Cheung, Ken et al. (2015) Pulsatile and steady components of blood pressure and subclinical cerebrovascular disease: the Northern Manhattan Study. J Hypertens 33:2115-22
Asdaghi, N; Coulter, J I; Modi, J et al. (2015) Statin therapy does not affect the radiographic and clinical profile of patients with TIA and minor stroke. AJNR Am J Neuroradiol 36:1076-80
Della-Morte, David; Dong, Chuanhui; Beecham, Ashley et al. (2015) Relationship between sirtuin and mitochondrial uncoupling protein genes and carotid artery stiffness. Transl Res 165:358-9
Hudson, Barry I; Gardener, Hannah; Liu-Mares, Wen et al. (2015) Serum soluble RAGE levels and carotid atherosclerosis: the Northern Manhattan Study (NOMAS). Atherosclerosis 240:17-20
Gutierrez, Jose; Cheung, Ken; Bagci, Ahmet et al. (2015) Brain Arterial Diameters as a Risk Factor for Vascular Events. J Am Heart Assoc 4:e002289
Gutierrez, Jose; Elkind, Mitchell S V; Gomez-Schneider, Maia et al. (2015) Compensatory intracranial arterial dilatation in extracranial carotid atherosclerosis: the Northern Manhattan study. Int J Stroke 10:843-8

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