The candidate proposes a multifaceted mentoring, career development, and research plan in patient- oriented research (POR) on genetic determinants of unexplained phenotypes of subclinical carotid atherosclerosis with the goal of future prevention of stroke. This plan will build on the candidate's established strengths in assessment of carotid ultrasound imaging markers, epidemiology, and current genetic project. This proposal will provide opportunities for junior trainees to obtain training in POR. The K24 award will allow for protected time so that the candidate can devote 90% of her professional effort towards mentoring and developing a formal mentorship program for residents and fellows (The Resident and Fellow Clinician Researcher Program in Neurology) and other trainees, and towards her research and career development in genetic epidemiology. The mentorship program will include (1) Didactic lectures on research methodology, epidemiology, analytical methods, genetics, and scientific writing;(2) Organizing research meetings, seminars, and conferences;(3) Helping trainees to develop their research projects;and (4) One-on-one mentoring. This K24 award will include professional and research career development for the candidate to gain new knowledge and skills in genetic epidemiology. The candidate ongoing POR on the candidate genes and subclinical carotid atherosclerosis will serve as a background for the primary aims of the proposed research to (1) identify individuals with unexplained subclinical atherosclerosis (USA) and unexplained protection against atherosclerosis (UPA) by generating residual scores in the multivariable regression model of subclinical carotid phenotypes fitted from the traditional vascular risk factors;(2) identify alleles associated with USA and UPA by performing a genome wide association study;and (3) assess the 3- year change in carotid plaque burden and identify alleles associated with this change in the sample of UPA and USA. This K24 award will help achieving the candidate's long-term goals in enhancing POR, establishing formal POR mentorship program, providing resources to perform independent research ideas for trainees, and creating an inspiring intellectual environment needed to increase the number of physician-scientists capable of carrying out modern and rigorous POR in neurology. 1

Public Health Relevance

Stroke is a leading cause of death and disability. This project is designed to discover new genetic determinants of subclinical atherosclerosis, a precursor of stroke, and to mentor young trainees in research. Finding genetic markers for precursors of stroke would lead to early identification of persons at high risk for stroke through genetic screening. These findings would improve stroke prevention, which is of great public health importance.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24NS062737-04
Application #
8325146
Study Section
Special Emphasis Panel (ZNS1-SRB-M (71))
Program Officer
Gwinn, Katrina
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$199,501
Indirect Cost
$14,778
Name
University of Miami School of Medicine
Department
Neurology
Type
Schools of Medicine
DUNS #
052780918
City
Coral Gables
State
FL
Country
United States
Zip Code
33146
Della-Morte, David; Dong, Chuanhui; Beecham, Ashley et al. (2015) Relationship between sirtuin and mitochondrial uncoupling protein genes and carotid artery stiffness. Transl Res 165:358-9
Rundek, Tatjana; Brown, Devin L (2014) Socioeconomic status and subclinical atherosclerosis: are we closing disparity gaps? Stroke 45:948-9
Della-Morte, David; Wang, Liyong; Beecham, Ashley et al. (2014) Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics. J Neurol Sci 344:27-31
Hudson, Barry I; Dong, Chuanhui; Gardener, Hannah et al. (2014) Serum levels of soluble receptor for advanced glycation end-products and metabolic syndrome: the Northern Manhattan Study. Metabolism 63:1125-30
Rundek, Tatjana; Brown, Scott C; Wang, Kefeng et al. (2014) Accreditation status and geographic location of outpatient vascular testing facilities among Medicare beneficiaries: the VALUE (Vascular Accreditation, Location & Utilization Evaluation) study. Vasc Med 19:376-84
Ramos, Alberto R; Dong, Chuanhui; Rundek, Tatjana et al. (2014) Sleep duration is associated with white matter hyperintensity volume in older adults: the Northern Manhattan Study. J Sleep Res 23:524-30
Wang, Liyong; Rundek, Tatjana; Beecham, Ashley et al. (2014) Genome-wide interaction study identifies RCBTB1 as a modifier for smoking effect on carotid intima-media thickness. Arterioscler Thromb Vasc Biol 34:219-25
Monteith, Teshamae; Gardener, Hannah; Rundek, Tatjana et al. (2014) Migraine, white matter hyperintensities, and subclinical brain infarction in a diverse community: the northern Manhattan study. Stroke 45:1830-2
Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G et al. (2014) Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh. Toxicol Appl Pharmacol 276:195-203
Alsulaimani, Sara; Gardener, Hannah; Elkind, Mitchell S V et al. (2013) Elevated homocysteine and carotid plaque area and densitometry in the Northern Manhattan Study. Stroke 44:457-61

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