This K24 proposal is a request for support for patient-oriented mentoring in the domain CNS mechanisms in pain and analgesic processing in humans. Pain continues to be a significant health problem in the US and functional imaging has already changed the domain of our insights into pain processing by providing novel insights into CNS plasticity, degeneration, and novel circuitry involved in pain processing in health and disease. Training of young scientists in a manner that provides a sound solid and supportive environment in an integrated, multidisciplinary program within the Harvard system will contribute to future enrollment of scientists in this domain. The proposal outlines a plan for mentoring that relates to 4 aspects of ongoing research in our pain and analgesia imaging neurosicence (p.a.i.n.) group at Harvard and include: (1) Mechanisms of Human Disease (e.g., migraine and trigeminal pain;pediatric pain);(2) Development of New Technologies (e.g., technologies for objective measures in the operating room);(3) Therapeutic Interventions (e.g., novel drug evaluation);and (4) Clinical Trials using fMRI. In addition the proposal defines specific training components that would enhance his mentoring abilities that include management courses and courses in cognitive sciences at the Massachusetts Institute of Technology and Harvard University. The candidate a track record in mentoring both clinicians and basic scientists, including K awards, and have a strong network of collaborators involved in our research program. The applicant is fully committed to mentoring and is in a very good position to do this at this point in his career. Providing objective indices of pain and analgesia would be a significant step forward in alleviating pain and suffering and the development of analgesics.

Public Health Relevance

Providing objective indices of pain and analgesia would be a significant step forward in alleviating pain and suffering and the development of analgesics. There is a critical need for the training young investigators in Patient Oriented Research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24NS064050-04
Application #
8110513
Study Section
NST-2 Subcommittee (NST)
Program Officer
Porter, Linda L
Project Start
2008-08-15
Project End
2012-03-31
Budget Start
2011-07-01
Budget End
2012-03-31
Support Year
4
Fiscal Year
2011
Total Cost
$43,116
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
046514535
City
Belmont
State
MA
Country
United States
Zip Code
02478
Becerra, Lino; Bishop, James; Barmettler, Gabi et al. (2017) Brain network alterations in the inflammatory soup animal model of migraine. Brain Res 1660:36-46
Borsook, David (2017) Opioidergic tone and pain susceptibility: interactions between reward systems and opioid receptors. Pain 158:185-186
Simons, Laura E; Sieberg, Christine B; Conroy, Caitlin et al. (2017) Children With Chronic Pain: Response Trajectories After Intensive Pain Rehabilitation Treatment. J Pain :
Youssef, Andrew M; Ludwick, Allison; Wilcox, Sophie L et al. (2017) In child and adult migraineurs the somatosensory cortex stands out … again: An arterial spin labeling investigation. Hum Brain Mapp 38:4078-4087
Bajic, Dusica; Craig, Michael M; Mongerson, Chandler R L et al. (2017) Identifying Rodent Resting-State Brain Networks with Independent Component Analysis. Front Neurosci 11:685
Hodkinson, Duncan J; Wilcox, Sophie L; Veggeberg, Rosanna et al. (2016) Increased Amplitude of Thalamocortical Low-Frequency Oscillations in Patients with Migraine. J Neurosci 36:8026-36
Elman, Igor; Borsook, David (2016) Common Brain Mechanisms of Chronic Pain and Addiction. Neuron 89:11-36
Rosenthal, Perry; Borsook, David; Moulton, Eric A (2016) Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye. Invest Ophthalmol Vis Sci 57:5285-5287
Hodkinson, Duncan J; Veggeberg, Rosanna; Kucyi, Aaron et al. (2016) Cortico-Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine. eNeuro 3:
George, E; Elman, I; Becerra, L et al. (2016) Pain in an era of armed conflicts: Prevention and treatment for warfighters and civilian casualties. Prog Neurobiol 141:25-44

Showing the most recent 10 out of 86 publications