Program Director/Principal Investigator (Last, First, Middle): Leblond, Frederic PROJECT SUMMARY (Seeinstructions): Before changing fields to optical imaging, the candidate has worked doing research in elementary particle physics and general relativity in the area of superstring theory. The long term career goal of the candidate is to become an independent researcher who has a unique set of knowledge and breadth of experience in numerical and analytical modeling as well as in biomedical engineering and medical sciences in order to develop new medical imaging tools and applications contributing to understanding tumor management. The immediate goal of the candidate is to upgrade an existing hybrid x-ray/near-infrared tomography system for pre-clinical time-domain measurements, making it optimal for imaging glioma tumors grown in mice. The main research objective of this proposal is to develop new data acquisition methods and algorithms to create tomography images that provide synergistic anatomical and functional information pertaining to glioma tumor growth. Fluorescence molecular tomography and diffuse optical tomography studies will be performed based on different optical markers potentially providing complementaryinformation. The proposed methods will use structural anatomical images from x-ray tomography as prior information enhancing the utility of optical tomography data. The research will be conducted in synergy with a clinical trial underway at Dartmouth College evaluating how glioma tumor resection guided by fluoresence imaging can positively affect patient survival. Darmouth has significant resources in the field of medical and engineering graduate education, and the candidate will use this career transition award to train at Dartmouth Hitchcock Medical Center, the Medical School and the Norris Cotton Cancer Center, with a central appointment in the Engineering School. The candidate's research career will be developed by (i) taking courses in medical engineering, tissue biochemistry and biostatistics, (ii)taking part in related events and lectures, (iii)attending group meetings at the NCI funded Cancer Center, (iv) presenting research results at oncology, radiology and imaging conferences, (v) planning with scientists working in biomedical companies developing pre-clinical instruments, and (vi)making use of the NCI resources in molecular imaging agent development.

Public Health Relevance

(Seeinstructions): -The proposed project will lead to the development of a pre-clinical imaging system that can be used to develop and test novel therapies designed to treat certain forms of cancer -The results of this research will help us understand better the dynamics of a glioma brain tumor growth and how they can be tracked and detected diagnostically.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Mentored Quantitative Research Career Development Award (K25)
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Subcommittee G - Education (NCI)
Program Officer
Jakowlew, Sonia B
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Dartmouth College
Biomedical Engineering
Schools of Engineering
United States
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Valdés, Pablo A; Jacobs, Valerie; Harris, Brent T et al. (2015) Quantitative fluorescence using 5-aminolevulinic acid-induced protoporphyrin IX biomarker as a surgical adjunct in low-grade glioma surgery. J Neurosurg 123:771-80
Tichauer, Kenneth M; Holt, Robert W; El-Ghussein, Fadi et al. (2013) Dual-tracer background subtraction approach for fluorescent molecular tomography. J Biomed Opt 18:16003
Glaser, Adam K; Davis, Scott C; McClatchy, David M et al. (2013) Projection imaging of photon beams by the CÌŒerenkov effect. Med Phys 40:012101
Valdés, Pablo A; Leblond, Frederic; Jacobs, Valerie L et al. (2012) Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci Rep 2:798
Roberts, David W; Valdés, Pablo A; Harris, Brent T et al. (2012) Adjuncts for maximizing resection: 5-aminolevuinic acid. Clin Neurosurg 59:75-8
Holt, Robert W; Tichauer, Kenneth M; Dehghani, Hamid et al. (2012) Multiple-gate time domain diffuse fluorescence tomography allows more sparse tissue sampling without compromising image quality. Opt Lett 37:2559-61
Bonfert-Taylor, Petra; Leblond, Frederic; Holt, Robert W et al. (2012) Information loss and reconstruction in diffuse fluorescence tomography. J Opt Soc Am A Opt Image Sci Vis 29:321-30
Valdes, P A; Leblond, F; Kim, A et al. (2012) A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery. Opt Lett 37:1817-9
Roberts, David W; Valdés, Pablo A; Harris, Brent T et al. (2012) Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid). Neurosurg Clin N Am 23:371-7
Konecky, Soren D; Owen, Chris M; Rice, Tyler et al. (2012) Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models. J Biomed Opt 17:056008

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