Program Director/Principal Investigator (Last, First, Middle): Leblond, Frederic PROJECT SUMMARY (Seeinstructions): Before changing fields to optical imaging, the candidate has worked doing research in elementary particle physics and general relativity in the area of superstring theory. The long term career goal of the candidate is to become an independent researcher who has a unique set of knowledge and breadth of experience in numerical and analytical modeling as well as in biomedical engineering and medical sciences in order to develop new medical imaging tools and applications contributing to understanding tumor management. The immediate goal of the candidate is to upgrade an existing hybrid x-ray/near-infrared tomography system for pre-clinical time-domain measurements, making it optimal for imaging glioma tumors grown in mice. The main research objective of this proposal is to develop new data acquisition methods and algorithms to create tomography images that provide synergistic anatomical and functional information pertaining to glioma tumor growth. Fluorescence molecular tomography and diffuse optical tomography studies will be performed based on different optical markers potentially providing complementaryinformation. The proposed methods will use structural anatomical images from x-ray tomography as prior information enhancing the utility of optical tomography data. The research will be conducted in synergy with a clinical trial underway at Dartmouth College evaluating how glioma tumor resection guided by fluoresence imaging can positively affect patient survival. Darmouth has significant resources in the field of medical and engineering graduate education, and the candidate will use this career transition award to train at Dartmouth Hitchcock Medical Center, the Medical School and the Norris Cotton Cancer Center, with a central appointment in the Engineering School. The candidate's research career will be developed by (i) taking courses in medical engineering, tissue biochemistry and biostatistics, (ii)taking part in related events and lectures, (iii)attending group meetings at the NCI funded Cancer Center, (iv) presenting research results at oncology, radiology and imaging conferences, (v) planning with scientists working in biomedical companies developing pre-clinical instruments, and (vi)making use of the NCI resources in molecular imaging agent development.

Public Health Relevance

(Seeinstructions): -The proposed project will lead to the development of a pre-clinical imaging system that can be used to develop and test novel therapies designed to treat certain forms of cancer -The results of this research will help us understand better the dynamics of a glioma brain tumor growth and how they can be tracked and detected diagnostically.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Mentored Quantitative Research Career Development Award (K25)
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Subcommittee G - Education (NCI)
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Jakowlew, Sonia B
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Dartmouth College
Biomedical Engineering
Schools of Engineering
United States
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Tichauer, Kenneth M; Holt, Robert W; El-Ghussein, Fadi et al. (2013) Dual-tracer background subtraction approach for fluorescent molecular tomography. J Biomed Opt 18:16003
Bonfert-Taylor, Petra; Leblond, Frederic; Holt, Robert W et al. (2012) Information loss and reconstruction in diffuse fluorescence tomography. J Opt Soc Am A Opt Image Sci Vis 29:321-30
Leblond, Frederic; Tichauer, Kenneth M; Holt, Robert W et al. (2011) Toward whole-body optical imaging of rats using single-photon counting fluorescence tomography. Opt Lett 36:3723-5
Pogue, Brian W; Davis, Scott C; Leblond, Frederic et al. (2011) Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value. Philos Trans A Math Phys Eng Sci 369:4531-57
Valdes, Pablo A; Kim, Anthony; Leblond, Frederic et al. (2011) Combined fluorescence and reflectance spectroscopy for in vivo quantification of cancer biomarkers in low- and high-grade glioma surgery. J Biomed Opt 16:116007
Hadjipanayis, Costas G; Jiang, Huabei; Roberts, David W et al. (2011) Current and future clinical applications for optical imaging of cancer: from intraoperative surgical guidance to cancer screening. Semin Oncol 38:109-18
Leblond, F; Ovanesyan, Z; Davis, S C et al. (2011) Analytic expression of fluorescence ratio detection correlates with depth in multi-spectral sub-surface imaging. Phys Med Biol 56:6823-37
Valdes, Pablo A; Leblond, Frederic; Kim, Anthony et al. (2011) Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker. J Neurosurg 115:11-7
Roberts, David W; Vald├ęs, Pablo A; Harris, Brent T et al. (2011) Coregistered fluorescence-enhanced tumor resection of malignant glioma: relationships between ?-aminolevulinic acid-induced protoporphyrin IX fluorescence, magnetic resonance imaging enhancement, and neuropathological parameters. Clinical article. J Neurosurg 114:595-603
Zhu, Q; Dehghani, H; Tichauer, K M et al. (2011) A three-dimensional finite element model and image reconstruction algorithm for time-domain fluorescence imaging in highly scattering media. Phys Med Biol 56:7419-34

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