This Career Development Award application is for Dr. Kadir Asian, a researcher with an engineering background, who has great potential to make a career transition into an independent biomedical researcher. Dr. Asian has extensive research experience in nanotechnology, where he made contributions to the literature in the field of new preparation techniques for metal nanoparticle-based biosensing platforms and their subsequent applications in bioassays for protein and DMA detection. However, Dr. Asian has limited knowledge and experience in spectroscopy and biochemistry and no experience in cell culture and molecular biology techniques, which are essential tools for a biomedical researcher. The proposed CDA will introduce him to biology through advanced biology courses, departmental seminars, professional society meetings and workshops on molecular biology laboratory techniques. As a result of the proposed research, Dr. Asian will gain advanced biochemistry and molecular biology knowledge as well as corresponding laboratory techniques to identify and propose solutions to biomedical problems and perform and direct related research. In addition, Dr. Asian will also be trained in advanced spectroscopic techniques by Dr. Chris D. Geddes, a world renowned expert in fluorescence spectroscopy, and mentored in biological techniques by Dr. Joseph P.Y. Kao, an expert in nano- and cell biology. Proposed mentored training in spectroscopy and biology combined with his nanotechnology background will usher Dr. Asian into an independent career in biomedical research. The proposed research plan includes: a year of intense learning of spectroscopy, biology and biology laboratory techniques through courses and workshops (1/4th effort);the development of new biosensing platforms (consistent with his past research, a 1/4th effort);the development of two clinically relevant assays (2/4th effort) 1) cardiac marker assays for a clinical setting, and 2) p53 protein assays. Cardiovascular diseases and cancer are amongst the leading causes of mortality in developed countries. In this proposed research, new assays that can detect the relevant indicator proteins for the assessment of these diseases at very early stage will be developed for the potential downstream use in a clinical setting.

National Institute of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Mentored Quantitative Research Career Development Award (K25)
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Special Emphasis Panel (ZEB1-OSR-D (M1))
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Erim, Zeynep
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Morgan State University
Schools of Arts and Sciences
United States
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Mohammed, Muzaffer; Syed, Maleeha F; Aslan, Kadir (2016) Microwave-accelerated bioassay technique for rapid and quantitative detection of biological and environmental samples. Biosens Bioelectron 75:420-6
Abel, Biebele; Kabir, Tabassum S; Odukoya, Babatunde et al. (2015) Enhancement of Colorimetric Response of Enzymatic Reactions by Thermally Evaporated Plasmonic Thin Films: Application to Glial Fibrillary Acidic Protein. Anal Methods 7:1175-1185
Abel, Biebele; Odukoya, Babatunde; Mohammed, Muzaffer et al. (2015) Enhancement of the Chemiluminescence Response of Enzymatic Reactions by Plasmonic Surfaces for Biosensing Applications. Nano Biomed Eng 7:92-101
Mohammed, Muzaffer; Aslan, Kadir (2014) Rapid and Sensitive Detection of p53 Based on DNA-Protein Binding Interactions Using Silver Nanoparticle Films and Microwave Heating. Nano Biomed Eng 6:76-84
Abel, Biebele; Aslan, Kadir (2014) Immobilization of enzymes to silver island films for enhanced enzymatic activity. J Colloid Interface Sci 415:133-42
Abel, Biebele; Clement, Travis C; Aslan, Kadir (2014) Enhancement of enzymatic colorimetric response by silver island films on high throughput screening microplates. J Immunol Methods 411:43-9
Mohammed, Muzaffer; Clement, Travis C; Aslan, Kadir (2014) Circular Bioassay Platforms for Applications in Microwave-Accelerated Techniques. Nano Biomed Eng 6:85-93
Mohammed, Muzaffer; Aslan, Kadir (2013) Design and Proof-of-Concept Use of a Circular PMMA Platform with 16-Well Sample Capacity for Microwave-Accelerated Bioassays. Nano Biomed Eng 5:10-19
Grell, Tsehai A J; Alabanza, Anginelle M; Gaskell, Karen et al. (2013) Microwave-accelerated surface modification of plasmonic gold thin films with self-assembled monolayers of alkanethiols. Langmuir 29:13209-16
Alabanza, Anginelle M; Mohammed, Muzaffer; Aslan, Kadir (2013) Crystallization of Amino Acids on a 21-well Circular PMMA Platform using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization. Nano Biomed Eng 5:140-147

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