Relating Diesel Exhaust Exposure to Respiratory and Immune Outcomes in Early Life The goal of this career development plan is to help Dr. Paloma Beamer, an environmental engineer, launch an independent biomedical research program. Asthma is a heterogeneous disease and the natural history, risk factors and clinical expression of the disease differ between asthma and wheezing phenotypes. Common to all forms of asthma is intermittent or persistent airway inflammation during critical time periods of development as a result of altered immune responses to viral infection, allergic sensitization, or environmental irritants. Vehicle exhaust is the primary source of air pollution in urban environments, where asthma prevalence rates are highest. Exposure to diesel exhaust has been associated with respiratory outcomes including asthma and decreased lung function in epidemiological studies and has also been linked with airway inflammation via in vivo human laboratory studies. The main objective of the research plan is to assess longitudinally the role of diesel-related pollutant exposure during infancy in developmental alterations of the immune and respiratory systems that lead to transient early life wheezing or asthma. The proposed project will use data collected from two on-going prospective birth cohort studies that provide extensive longitudinal data for 1730 children on IgE, cytokines, lung function and respiratory symptoms. To complete the aims, Dr. Beamer will use GIS techniques to model diesel-related pollution exposure based on birth and childhood addresses. She will then assess if diesel-related pollutant exposure in early life is associated with: (1) increased incidence of asthma-related respiratory symptoms;(2) decreased lung function;(3) increased bronchial responsiveness;(4) predominance of Th2 versus Th1 cytokine production and (5) increased allergic sensitization as measured by total and allergen-specific IgE and skin prick tests. Findings from these analyses will aid Dr. Beamer in designing age- appropriate interventions that she can evaluate in future community-based trials aimed at the primary prevention of asthma. This research plan forms the basis of a 5-year career development plan for Dr. Beamer under the mentorship of Dr. Fernando Martinez (respiratory diseases, epidemiology), Dr. Lynn Gerald (asthma, community-based research), Dr. Duane Sherrill (biostatistics), and Dr. Eric Betterton (atmospheric chemistry and physics). Additional collaborators include Dr. Anne Wright (asthma epidemiology) and Dr. Andrew Comrie (urban air pollution, spatial analysis). This interdisciplinary group has designed a career development program that includes (1) formal training in biostatistics, epidemiology, immunotoxicology, spatial analysis, intervention development and evaluation, (2) regular meetings with mentors and collaborators, (3) participation in seminars, (4) presenting results at scientific meetings, (5) publishing in peer-reviewed journals, and (6) submitting an R01. Completion of this career development plan will establish Dr. Beamer as a researcher at the interface of environmental engineering and epidemiology, and position her to design and evaluate novel interventions aimed at reducing the burden of respiratory disease from environmental exposures.

Public Health Relevance

Relating Diesel Exhaust Exposure to Respiratory and Immune Outcomes in Early Life The goal of this career development plan is to help Dr. Paloma Beamer, an environmental engineer, launch an independent research career focused on assessing how exposures to environmental pollutants may lead to development of respiratory disease, particularly in vulnerable and underserved populations. Completing the research project component of this proposal will help us understand if exposure to diesel-related pollutants as an infant results in alterations of the immune and respiratory systems that could result in early childhood wheezing or development of asthma. Dr. Beamer will use the findings from this proposal to engineer intervention strategies that can then be tested in community settings and hopefully help reduce the burden of wheezing in childhood.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
5K25HL103970-02
Application #
8320879
Study Section
Special Emphasis Panel (ZHL1-CSR-X (M1))
Program Officer
Tigno, Xenia
Project Start
2011-08-16
Project End
2016-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$131,117
Indirect Cost
$9,643
Name
University of Arizona
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Lothrop, Nathan; Hussaini, Khaleel; Billheimer, Dean et al. (2017) Community-level characteristics and environmental factors of child respiratory illnesses in Southern Arizona. BMC Public Health 17:516
Victory, Kerton R; Cabrera, Nolan L; Larson, Daniela et al. (2017) Comparison of Fluoride Levels in Tap and Bottled Water and Reported Use of Fluoride Supplementation in a United States-Mexico Border Community. Front Public Health 5:87
Carr, Tara F; Beamer, Paloma I; Rothers, Janet et al. (2017) Prevalence of Asthma in School Children on the Arizona-Sonora Border. J Allergy Clin Immunol Pract 5:114-120.e2
Beamer, Paloma I; Lothrop, Nathan; Lu, Zhenqiang et al. (2016) Spatial clusters of child lower respiratory illnesses associated with community-level risk factors. Pediatr Pulmonol 51:633-42
Loh, Miranda M; Sugeng, Anastasia; Lothrop, Nathan et al. (2016) Multimedia exposures to arsenic and lead for children near an inactive mine tailings and smelter site. Environ Res 146:331-9
Beamer, Paloma I; Klimecki, Walter T; Loh, Miranda et al. (2016) Response to García-Nieto et al. Comments on Beamer et al. Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media. Int. J. Environ. Res. Public Health 2016, 13, 521. Int J Environ Res Public Health 13:
Beamer, Paloma I; Klimecki, Walter T; Loh, Miranda et al. (2016) Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media. Int J Environ Res Public Health 13:
Reynolds, Kelly A; Beamer, Paloma I; Plotkin, Kevin R et al. (2015) The healthy workplace project: Reduced viral exposure in an office setting. Arch Environ Occup Health :1-6
Tsou, Ming-Chien; Özkaynak, Halûk; Beamer, Paloma et al. (2015) Mouthing activity data for children aged 7 to 35 months in Taiwan. J Expo Sci Environ Epidemiol 25:388-98
Beamer, Paloma I; Plotkin, Kevin R; Gerba, Charles P et al. (2015) Modeling of human viruses on hands and risk of infection in an office workplace using micro-activity data. J Occup Environ Hyg 12:266-75

Showing the most recent 10 out of 14 publications