Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning.
This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.
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|Zeng, Ling-Li; Wang, Danhong; Fox, Michael D et al. (2014) Neurobiological basis of head motion in brain imaging. Proc Natl Acad Sci U S A 111:6058-62|
|Fox, Michael D; Buckner, Randy L; Liu, Hesheng et al. (2014) Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc Natl Acad Sci U S A 111:E4367-75|
|Wang, Danhong; Liu, Hesheng (2014) Functional connectivity architecture of the human brain: not all the same. Neuroscientist 20:432-8|
|Wang, Danhong; Buckner, Randy L; Liu, Hesheng (2013) Cerebellar asymmetry and its relation to cerebral asymmetry estimated by intrinsic functional connectivity. J Neurophysiol 109:46-57|
|Mueller, Sophia; Wang, Danhong; Fox, Michael D et al. (2013) Individual variability in functional connectivity architecture of the human brain. Neuron 77:586-95|
|Ge, Manling; Wang, Danhong; Dong, Guoya et al. (2013) Transient impact of spike on theta rhythm in temporal lobe epilepsy. Exp Neurol 250:136-42|
|Qian, Tianyi; Zhou, Wenjing; Ling, Zhipei et al. (2013) Fast presurgical functional mapping using task-related intracranial high gamma activity. J Neurosurg 119:26-36|
|Stufflebeam, Steven M; Liu, Hesheng; Sepulcre, Jorge et al. (2011) Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg 114:1693-7|
|Sabuncu, Mert R; Desikan, Rahul S; Sepulcre, Jorge et al. (2011) The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol 68:1040-8|
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