Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning.

Public Health Relevance

This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
5K25NS069805-03
Application #
8441549
Study Section
NST-2 Subcommittee (NST)
Program Officer
Fureman, Brandy E
Project Start
2011-03-01
Project End
2016-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
3
Fiscal Year
2013
Total Cost
$179,077
Indirect Cost
$13,265
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Fox, Michael D; Qian, Tianyi; Madsen, Joseph R et al. (2016) Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. Neuroimage 124:714-23
Langs, Georg; Wang, Danhong; Golland, Polina et al. (2016) Identifying Shared Brain Networks in Individuals by Decoupling Functional and Anatomical Variability. Cereb Cortex 26:4004-14
Boes, Aaron D; Prasad, Sashank; Liu, Hesheng et al. (2015) Network localization of neurological symptoms from focal brain lesions. Brain 138:3061-75
Zhang, Miao; Lin, Qixiang; Lu, Jie et al. (2015) Pontine infarction: diffusion-tensor imaging of motor pathways-a longitudinal study. Radiology 274:841-50
Douw, Linda; DeSalvo, Matthew N; Tanaka, Naoaki et al. (2015) Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Ann Clin Transl Neurol 2:338-52
Mueller, Sophia; Wang, Danhong; Pan, Ruiqi et al. (2015) Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia. JAMA Psychiatry 72:552-60
Mueller, Sophia; Wang, Danhong; Fox, Michael D et al. (2015) Reliability correction for functional connectivity: Theory and implementation. Hum Brain Mapp 36:4664-80
Wang, Danhong; Buckner, Randy L; Fox, Michael D et al. (2015) Parcellating cortical functional networks in individuals. Nat Neurosci 18:1853-60
Wang, Danhong; Buckner, Randy L; Liu, Hesheng (2014) Functional specialization in the human brain estimated by intrinsic hemispheric interaction. J Neurosci 34:12341-52
Zeng, Ling-Li; Wang, Danhong; Fox, Michael D et al. (2014) Neurobiological basis of head motion in brain imaging. Proc Natl Acad Sci U S A 111:6058-62

Showing the most recent 10 out of 24 publications