The Candidate is a board certified Anatomic Pathologist and Neuropathologist with extensive experience in generating and studying genetically-modified mice to model disease pathogenesis and basic biological mechanisms. Dr. Tourtellotte's independent research program focuses on immediate early gene regulation in neurodevelopment and behavior, and it serves as a training program for undergraduate, predoctoral and postdoctoral students in mouse pathobiology research at Northwestern University. Specifically, Dr. Tourtellotte's research program focuses on: (1) molecular mechanisms mediating nerve-muscle interactions, (2) autonomic nervous system development and dysfunction and (3) the mechanisms of IKBKAP gene function in human familial dysautonomia. Dr. Tourtellotte also serves as a mentor to clinical pathology residents and fellows, many of whom are engaged in research projects that use murine pathobiology to model mechanisms of human disease. Dr. Tourtellotte is proposing to expand his mentoring role by helping to enhance the mouse pathobiology training and research infrastructure at Northwestern University. Through his leadership of the Transgenic and Targeted Mutagenesis Laboratory and the Mouse Phenotyping Core Laboratory at Northwestern University, he is proposing to enhance the training and service in mouse pathobiology research that is available to both junior and senior investigators who wish to use and/or develop mouse models for their own independent research programs. Dr. Tourtellotte is seeking career development support to enable him to decrease his clinical service commitment and focus his efforts on mouse pathobiology research and training. Specifically, he will continue to strengthen his independent research and training program and enhance mouse pathobiology related core laboratory resources and training programs at Northwestern University. The latter efforts will enable him to maximize his influence as a mentor to a future generation of mouse pathobiologists beyond the relatively small number of trainees he currently mentors in his independent research program.
(provided by applicant): Mouse pathobiology has become important for modern biomedical research because mice can be genetically manipulated with relative ease. Genetically modified mice serve as experimental model systems for studying disease mechanisms and for formulating therapies. The PI seeks support to train mouse pathobiologists who will be able to generate and manipulate mouse genetic models in their research programs.
|Folmsbee, Stephen Sai; Wilcox, Douglas R; Tyberghein, Koen et al. (2016) Î±T-catenin in restricted brain cell types and its potential connection to autism. J Mol Psychiatry 4:2|
|Marangoni, Roberta Goncalves; Korman, Benjamin D; Wei, Jun et al. (2015) Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheumatol 67:1062-73|
|Huang, Qi-Quan; Perlman, Harris; Birkett, Robert et al. (2015) CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis. Nat Commun 6:7086|
|Jackson, Marisa; Tourtellotte, Warren (2014) Neuron Culture from Mouse Superior Cervical Ganglion. Bio Protoc 4:|
|Fang, Feng; Shangguan, Anna J; Kelly, Kathleen et al. (2013) Early growth response 3 (Egr-3) is induced by transforming growth factor-Î² and regulates fibrogenic responses. Am J Pathol 183:1197-208|
|Idnani, Barkha Jay; Choksi, Dipti (2013) Re-treatment of Root Canal Therapy. Asian academic research journal of multidisciplinary 1:108-112|
|Quach, David H; Oliveira-Fernandes, Michelle; Gruner, Katherine A et al. (2013) A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci 33:4570-83|
|Bhalala, Oneil G; Pan, Liuliu; Sahni, Vibhu et al. (2012) microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci 32:17935-47|
|Enjin, Anders; LeÃ£o, Katarina E; Mikulovic, Sanja et al. (2012) Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Mol Cell Neurosci 49:322-32|
|Bhattacharyya, Swati; Wei, Jun; Tourtellotte, Warren G et al. (2012) Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis Tissue Repair 5:S18|
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