The candidate is an anatomic pathologist with advanced training in surgical pathology and human breast and prostate diagnostic pathology;his research training is in cancer molecular biology and molecular pathology. He has studied mouse pathology in the context of genetically engineered mouse models of cancer for the past decade. He is a proven mentor in mouse pathobiology teaching medical and veterinary pathology residents and fellows, graduate degree, medical and veterinary students. He has served as teaching faculty in several national and international training courses. The plan for mentoring sponsored by this award includes: 1) Establishment of a funded training position for MD or DVM candidates with prior pathology training. 2) Development of an annual course on mouse specific pathology for the United States and Canadian Academy of Pathology Annual Meeting. And, 3) Establishment of a regular mouse cancer pathology telepathology conference using Whole Slide Image/ Zoomify Communications Tool technology. The research plan in mouse pathobiology research will build on funded work in the candidate's laboratory. The focus is on the use of genetically engineered mice to understand basic mechanisms of cancer. In particular, the laboratory has shown that isolation of experimentally defined mammary pre-cancer with heterogeneous histopathology reveals a """"""""stem-like"""""""" behavior with pre-encoded cancer progression. The plan entails 1) Development of dissociation techniques and flow cytometry for isolation of specific cell subsets in mouse pre-cancers. 2) Characterize the histopathology of transplanted epithelial cells and 3) Isolate and define the progression events: a) pre-cancer to invasion and b) invasion to metastasis in the context of cell subset transplantation pathology. The environment is ideally suited to the objectives of this award. The UC Davis Center for Comparative Medicine and Mouse Biology Program has provided international leadership in the area of mouse pathobiology over the past decade. Relevance Statement: The genetically engineered mouse (GEM) has become the preeminent organism for modeling human disease. Understanding the pathobiology of the mouse is critical to the validity and success of this enterprise. Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Midcareer Investigator Award in Biomedical and Behavioral Research (K26)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Mirochnitchenko, Oleg
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Schmitz, Jennifer; Schwab, Julian; Schwenck, Johannes et al. (2016) Decoding Intratumoral Heterogeneity of Breast Cancer by Multiparametric In Vivo Imaging: A Translational Study. Cancer Res 76:5512-22
Borowsky, Alexander D; Bandhuvula, Padmavathi; Kumar, Ashok et al. (2012) Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues. J Lipid Res 53:1920-31
Dusek, Rachel L; Bascom, Jamie L; Vogel, Hannes et al. (2012) Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res 14:R65
Boucher, David L; Chen, Jane Qian; Cherry, Simon R et al. (2012) Establishment of clonal MIN-O transplant lines for molecular imaging via lentiviral transduction & in vitro culture. PLoS One 7:e39350
Mori, Hidetoshi; Borowsky, Alexander D; Bhat, Ramray et al. (2012) Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues. Am J Pathol 180:2249-56
Vinall, Ruth L; Chen, Jane Q; Hubbard, Neil E et al. (2012) Initiation of prostate cancer in mice by Tp53R270H: evidence for an alternative molecular progression. Dis Model Mech 5:914-20
Bandhuvula, Padmavathi; Honbo, Norman; Wang, Guan-Ying et al. (2011) S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. Am J Physiol Heart Circ Physiol 300:H1753-61
Rygh, Cecilie B; Qin, Shengping; Seo, Jai W et al. (2011) Longitudinal investigation of permeability and distribution of macromolecules in mouse malignant transformation using PET. Clin Cancer Res 17:550-9
de Leoz, Maria Lorna A; Young, Lawrence J T; An, Hyun Joo et al. (2011) High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics 10:M110.002717
Borowsky, Alexander D (2011) Choosing a mouse model: experimental biology in context--the utility and limitations of mouse models of breast cancer. Cold Spring Harb Perspect Biol 3:a009670

Showing the most recent 10 out of 19 publications