The objectives of this Pathway to Independence Award for Karen M. Rodrigue, Ph.D., are to deepen the candidate's expertise in the field of cognitive neuroscience to enable her to investigate novel questions regarding the role of vascular risk in brain and cognitive aging. The central aim of this project is to examine a vascular hypothesis of aging which investigates the role of general vascular risk factors, such as hypertension, and specific cerebrovascular mechanisms such as hypoperfusion, in shaping the course of neural and cognitive aging within a normal aging model. The proposed K99 phase of research focuses on this aim by testing the hypothesis that age-related alteration in regional brain perfusion predicts decline in the cognitive performance of healthy middle-aged and older adults. The mentored phase also examines the modifying effects of hypertension on neural activity in an fMRI paradigm, testing the hypothesis that differences in vascular health can explain age-related dedifferentiation of brain function. A cross-sectional individual differences approach with a lifespan sample will be used to test hypotheses in the K99 phase. The R00 phase extends the study of the impact of vascular health on neural and cognitive decline by examining vascular predictors of ?-amyloid deposition in normal aging. The objectives of this research proposal are in accord with the mission of the National Institute on Aging. Understanding the contributions of vascular health to successful, as well as pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population, and its amenability to prevention and treatment. The research skills and knowledge gained by the applicant during the completion of this project (e.g., training in fMRI, perfusion and PET imaging) along with the proposed coursework and professional development activities outlined in the training plan, will enable her to successfully transition to an independent position as a cognitive neuroscientist.

Public Health Relevance

The present proposal examines a vascular hypothesis of aging which investigates the role of general vascular risk factors, such as hypertension, and specific cerebrovascular mechanisms such as hypoperfusion, in shaping the course of neural and cognitive aging within a normal aging model. Understanding the contributions of vascular health to successful, as well as pathological aging is fundamentally important given both the prevalence of vascular risk in the aging population, and its amenability to prevention and treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Career Transition Award (K99)
Project #
5K99AG036848-02
Application #
8149838
Study Section
Special Emphasis Panel (ZAG1-ZIJ-7 (02))
Program Officer
Wagster, Molly V
Project Start
2010-09-30
Project End
2012-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2011
Total Cost
$89,546
Indirect Cost
Name
University of Texas-Dallas
Department
Type
Other Domestic Higher Education
DUNS #
800188161
City
Richardson
State
TX
Country
United States
Zip Code
75080
Foster, Chris M; Kennedy, Kristen M; Rodrigue, Karen M (2017) Differential Aging Trajectories of Modulation of Activation to Cognitive Challenge in APOE ?4 Groups: Reduced Modulation Predicts Poorer Cognitive Performance. J Neurosci 37:6894-6901
Kennedy, Kristen M; Rieck, Jenny R; Boylan, Maria A et al. (2017) Functional magnetic resonance imaging data of incremental increases in visuo-spatial difficulty in an adult lifespan sample. Data Brief 11:54-60
Rieck, Jenny R; Rodrigue, Karen M; Boylan, Maria A et al. (2017) Age-related reduction of BOLD modulation to cognitive difficulty predicts poorer task accuracy and poorer fluid reasoning ability. Neuroimage 147:262-271
Kennedy, Kristen M; Rodrigue, Karen M; Bischof, Gérard N et al. (2015) Age trajectories of functional activation under conditions of low and high processing demands: an adult lifespan fMRI study of the aging brain. Neuroimage 104:21-34
Liu, Peiying; Hebrank, Andrew C; Rodrigue, Karen M et al. (2013) A comparison of physiologic modulators of fMRI signals. Hum Brain Mapp 34:2078-88
Rodrigue, Karen M; Rieck, Jennifer R; Kennedy, Kristen M et al. (2013) Risk factors for ?-amyloid deposition in healthy aging: vascular and genetic effects. JAMA Neurol 70:600-6
Rodrigue, Karen M; Daugherty, Ana M; Haacke, E Mark et al. (2013) The role of hippocampal iron concentration and hippocampal volume in age-related differences in memory. Cereb Cortex 23:1533-41
Rodrigue, K M; Kennedy, K M; Devous Sr, M D et al. (2012) ýý-Amyloid burden in healthy aging: regional distribution and cognitive consequences. Neurology 78:387-95
Park, Joonkoo; Carp, Joshua; Kennedy, Kristen M et al. (2012) Neural broadening or neural attenuation? Investigating age-related dedifferentiation in the face network in a large lifespan sample. J Neurosci 32:2154-8
Lu, Hanzhang; Xu, Feng; Rodrigue, Karen M et al. (2011) Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex 21:1426-34