None provided.

Public Health Relevance

: My project seeks to understand the role of pyruvate kinase as regulator of cancer metabolism. Insights into glutamine influx of proliferating cells will reveal new drug targets and generate new regimes for diagnosis and treatment of cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Career Transition Award (K99)
Project #
1K99CA154887-01
Application #
8029618
Study Section
Subcommittee G - Education (NCI)
Program Officer
Schmidt, Michael K
Project Start
2011-07-21
Project End
2013-06-30
Budget Start
2011-07-21
Budget End
2012-06-30
Support Year
1
Fiscal Year
2011
Total Cost
$88,646
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Tiffen, Jessamy C; Gallagher, Stuart J; Tseng, Hsin-Yi et al. (2016) EZH2 as a mediator of treatment resistance in melanoma. Pigment Cell Melanoma Res 29:500-7
Wilson, Stephen; Qi, Jianfei; Filipp, Fabian V (2016) Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines. Sci Rep 6:32611
Tiffen, Jessamy; Wilson, Stephen; Gallagher, Stuart J et al. (2016) Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma. Neoplasia 18:121-32
Edwards, Lauren; Gupta, Rohit; Filipp, Fabian Volker (2016) Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression. Mol Cancer Res 14:196-206
Zielinski, Daniel C; Filipp, Fabian V; Bordbar, Aarash et al. (2015) Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis. Nat Commun 6:7101
Filipp, Fabian V (2013) Cancer metabolism meets systems biology: Pyruvate kinase isoform PKM2 is a metabolic master regulator. J Carcinog 12:14
Filipp, Fabian V; Ratnikov, Boris; De Ingeniis, Jessica et al. (2012) Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma. Pigment Cell Melanoma Res 25:732-9
Filipp, Fabian V; Scott, David A; Ronai, Ze'ev A et al. (2012) Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res 25:375-83
Fang, Changming; Filipp, Fabian V; Smith, Jeffrey W (2012) Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXRα. J Lipid Res 53:664-73
Scott, David A; Richardson, Adam D; Filipp, Fabian V et al. (2011) Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem 286:42626-34

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