My project seeks to understand the role of pyruvate kinase as regulator of cancer metabolism. Insights into glutamine influx of proliferating cells will reveal new drug targets and generate new regimes for diagnosis and treatment of cancer patients.
|Filipp, Fabian V; Scott, David A; Ronai, Ze'ev A et al. (2012) Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells. Pigment Cell Melanoma Res 25:375-83|
|Fang, Changming; Filipp, Fabian V; Smith, Jeffrey W (2012) Unusual binding of ursodeoxycholic acid to ileal bile acid binding protein: role in activation of FXR?. J Lipid Res 53:664-73|
|Scott, David A; Richardson, Adam D; Filipp, Fabian V et al. (2011) Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. J Biol Chem 286:42626-34|