The candidate is seeking a Pathway to Independence Award to provide an intensive research, training and career development program as an epidemiologist and developing investigator at the Stanford University. The long-term goal is to become a leading investigator in the field of environmental perinatal epidemiology with the intention of informing clinical decisions and environmental policy to improve pediatric health. To continue her progress towards this goal, the candidate is proposing a study addressing specific hypotheses of the role of social factors, namely neighborhood deprivation and acculturation, in the relationship between traffic-related air pollution and adverse birth outcomes. The exposures of interest include ambient air pollutants and traffic density. The adverse birth outcomes include structural birth defects and outcomes related to birth weight and gestational age. She will use semi-parametric methods estimate population- level effects with a more causal parameters of interest. She will develop and use indices to characterize neighborhood deprivation and acculturation and investigate these factors as potential effect modifiers. With the use of geographic information systems (GIS) tools and publicly available data, the candidate will characterize the social context of the neighborhood of each participant to gain more insight into the interaction of the physical and social environment in determining health outcomes. The data comprising these indices will be shared via an online database for researchers to use for future studies in the San Joaquin Valley of California. This research supports the National Institutes of Health's mission to prevent disease and improve the health and well-being of Americans and the NIEHS's mission to build integrated environmental health research programs to address the cross-cutting problems in human biology and human disease. With the robust research program that the candidate has proposed, she plan for future training and the strong team of mentors and advisors, and she intends to become an independent researcher and prepare herself to compete for R01 funding to: 1) expand the geographic and temporal range;2) combine with databases that include additional neonatal outcomes;and 3) create a more rich exposure assessment by collecting more data on additional pollutants such as pesticides and air toxics.

Public Health Relevance

The proposed research will improve our understanding of the environmental and social determinants of adverse birth outcomes. This research will improve public health research by providing informing clinical recommendations and policies concerning vehicle emissions and land use in the San Joaquin Valley of California.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Career Transition Award (K99)
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Special Emphasis Panel (ZES1)
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Finn, Symma
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Stanford University
Schools of Medicine
United States
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Huang, Hongtai; Woodruff, Tracey J; Baer, Rebecca J et al. (2018) Investigation of association between environmental and socioeconomic factors and preterm birth in California. Environ Int 121:1066-1078
Padula, Amy M; Yang, Wei; Lurmann, Fredrick W et al. (2018) Prenatal exposure to air pollution, maternal diabetes and preterm birth. Environ Res 170:160-167
Padula, Amy M; Yang, Wei; Carmichael, Suzan L et al. (2017) Air pollution, neighborhood acculturation factors, and neural tube defects among Hispanic women in California. Birth Defects Res 109:403-422
Padula, Amy M; Yang, Wei; Schultz, Kathleen et al. (2016) Gene variants as risk factors for gastroschisis. Am J Med Genet A 170:2788-2802
Cossi, Malin; Zuta, Shkelqime; Padula, Amy M et al. (2015) Role of infant sex in the association between air pollution and preterm birth. Ann Epidemiol 25:874-6
Padula, Amy M; Balmes, John R; Eisen, Ellen A et al. (2015) Ambient polycyclic aromatic hydrocarbons and pulmonary function in children. J Expo Sci Environ Epidemiol 25:295-302
Padula, Amy M; Yang, Wei; Carmichael, Suzan L et al. (2015) Air Pollution, Neighbourhood Socioeconomic Factors, and Neural Tube Defects in the San Joaquin Valley of California. Paediatr Perinat Epidemiol 29:536-45
Padula, Amy M; Mortimer, Kathleen M; Tager, Ira B et al. (2014) Traffic-related air pollution and risk of preterm birth in the San Joaquin Valley of California. Ann Epidemiol 24:888-95e4
Yang, Wei; Carmichael, Suzan L; Roberts, Eric M et al. (2014) Residential agricultural pesticide exposures and risk of neural tube defects and orofacial clefts among offspring in the San Joaquin Valley of California. Am J Epidemiol 179:740-8
Shaw, Gary M; Yang, Wei; Roberts, Eric et al. (2014) Early pregnancy agricultural pesticide exposures and risk of gastroschisis among offspring in the San Joaquin Valley of California. Birth Defects Res A Clin Mol Teratol 100:686-94

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