The National institutes of Health's RFA for Clinical and Translational Science Awards has catalyzed the efforts of academic medical institutions to remove impediments to the translation of fundamental discoveries into better health for our citizens and rectify shortages within the clinical and translational workforce. This proposal of the Clinical and Translational Science Institute of Southeast Wisconsin is tailored to the needs and resources of the biomedical enterprise In the region and offers a novel and transformative plan to achieve the above mentioned goals. Building on the long collaborative history among the major academic and healthcare institutions In our area, we have constructed a unique academic-community partnership comprised ofthe Medical College of Wisconsin, University of Wisconsin-Milwaukee, Marquette University, Milwaukee School of Engineering, Froedtert Hospital, Children's Hospital of Wisconsin, Zablocki VA Medical Center and BloodCenter of Wisconsin, set in the milieu of a large urban community with remarkable ethnic and social diversity. Our proposal brings together the various resources of the partner institutions to identify and address the obstacles that impede the conduct of clinical and translational research in the region. The transforming environment of our CTSI focuses on the interdependency and interrelationship of our research teams and the relationship of the key functions to the rest of the CTSA in their integrating, enabling and effecting roles. To accomplish this transformation, we propose (and have begun to implement during the pre-award years) 1) To develop a distinct """"""""Academic Home"""""""" for the discipline of clinical and translational science - the Clinical and Translational Science Institute (CTSI) -which transcends intra-and inter-institutional barrier, empowers experienced leadership to have the authority and resources to promote, facilitate, coordinate and foster the continuum of translational research from bench to bedside (T1), to clinical practices (T2), and to our communities (T3);2) To increase the number of investigators participating in clinical research through innovative programs within the CTSI;3) To develop, align, and coordinate infrastructure across institutions to provide our scientists with the resources required for Clinical and Translational research;and 4) To engage clinical practices and the community in research h that enhances public health. Our Community Engagement program is an MCW strength. We will build on an existing network ofthe Healthier Wisconsin Partnership Program (HWPP) and expertise and resources of our partners in medical, biomedical engineering, dentistry, nursing, social sciences and allied health disciplines to implement novel community based (T3) research programs. We believe our CTSA model is transferable to other similarly-sized academic research communities across the country.

Public Health Relevance

Better preventive measures, more accurate diagnostics, and more effective therapies are badly needed to improve the health of our citizens. This application provides a novel and comprehensive mechanism to address these needs through research and education. It creates a borderless, collaborative environment in SE Wisconsin for biomedical researchers, healthcare providers, educators, citizens, and industry to work together synergistically and translate the fundamental discoveries into better health for our citizens.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000056-05
Application #
8655190
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Wilson, Todd
Project Start
2010-07-01
Project End
2015-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
5
Fiscal Year
2014
Total Cost
$180,586
Indirect Cost
$18,400
Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Maranto, Cristina; Udhane, Vindhya; Hoang, David T et al. (2018) STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA Repair. Clin Cancer Res 24:1917-1931
Flister, Michael J; Bergom, Carmen (2018) Genetic Modifiers of the Breast Tumor Microenvironment. Trends Cancer 4:429-444
Kumar, S K; Dispenzieri, A; Fraser, R et al. (2018) Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time. Leukemia 32:986-995
Babaei, A; Szabo, A; Yorio, S D et al. (2018) Pressure exposure and catheter impingement affect the recorded pressure in the Manoscan 360™ system. Neurogastroenterol Motil :
McVey, Alana J; Schiltz, Hillary K; Haendel, Angela D et al. (2018) Social difficulties in youth with autism with and without anxiety and ADHD symptoms. Autism Res 11:1679-1689
Brosig, Cheryl L; Bear, Laurel; Allen, Sydney et al. (2018) Neurodevelopmental outcomes at 2 and 4 years in children with congenital heart disease. Congenit Heart Dis 13:700-705
Hopp, Elizabeth E; Cossette, Stephanie M; Kumar, Suresh N et al. (2017) Sucrose Non-Fermenting Related Kinase Expression in Ovarian Cancer and Correlation with Clinical Features. Cancer Invest 35:456-462
Sampath, Venkatesh; Bhandari, Vineet; Berger, Jessica et al. (2017) A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. Pediatr Res 81:582-588
Prisco, Anthony R; Aliseda, Alberto; Beckman, Jennifer A et al. (2017) Impact of LVAD Implantation Site on Ventricular Blood Stagnation. ASAIO J 63:392-400
Mahindra, A; Hari, P; Fraser, R et al. (2017) Autologous hematopoietic cell transplantation for multiple myeloma patients with renal insufficiency: a center for international blood and marrow transplant research analysis. Bone Marrow Transplant 52:1616-1622

Showing the most recent 10 out of 64 publications