The vision of the University of Cincinnati Academic Health Center (AHC) Institutional CTSA is to create an environment to facilitate translating discoveries to clinical application. Our new academic home for clinical and translational research, the Center for Clinical and Translational Science and Training (CCTST), is beginning to transform the research environment within the AHC and our affiliated partners in other areas of the University, the community, and industry. The CCTST will coordinate and plan the overall direction of AHC research infrastructure and training opportunities;serve investigators'needs from project concept to completion;optimize skills and foster career development of both new and experienced investigators;and ensure that community input informs research processes, and that AHC discoveries are translated to the community. The CCTST will coordinate and leverage our existing strengths and develop new initiatives. Through Research Central, researchers will have easy access to centralized study design, biostatistical, bioinformatics, regulatory, and community engagement support. The new Pilot &Collaborative Studies core will expand the highly successful pilot funding program at Cincinnati Children's Hospital Medical Center (CCHMC) to the entire AHC. Biomedical informatics will be coordinated across the AHC. A new K12 program and greatly expanded educational offerings, including a new Certificate in Clinical and Translational Research, will be developed, building on the success of our Dean's Scholars in Clinical Research and K30- funded MS in Clinical and Translational Research programs. Through our community engagement program, we will further bi-directional research linkages with the local community, breaking down bureaucratic barriers by creating IRBs that can coordinate community-based research. Expanding services such as nursing/coordinator support and sample processing provided by the existing General Clinical Research Center (GCRC) at CCHMC and the Cincinnati Veterans Affairs Medical Center will promote patient-oriented research for populations outside the GCRC in the community. New translational technologies, including proteomics, drug discovery, imaging, nanomedicine, gene transfer and stem cell biology and translational and molecular disease modeling, will be made more accessible to researchers. Throughout, we will utilize a quality improvement model to evaluate our progress. These efforts will facilitate transforming clinical and translational research at the AHC, leading to improved health outcomes in the community.

Public Health Relevance

Institutional CTSA grants are critical to creating academic homes for clinical and translational researchers and furthering clinical and translational science. The University of Cincinnati Institutional CTSA would transform our local research environment and contribute to the CTSA Consortium.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000078-05
Application #
8473959
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Merchant, Carol
Project Start
2009-04-03
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
5
Fiscal Year
2013
Total Cost
$692,255
Indirect Cost
$43,390
Name
University of Cincinnati
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Copp, Kathleen; DeFranco, Emily A; Kleiman, Jeanne et al. (2018) Nutrition Support Team Guide to Maternal Diet for the Human-Milk-Fed Infant. Nutr Clin Pract 33:687-693
Bader, Kenneth B; Haworth, Kevin J; Maxwell, Adam D et al. (2018) Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro. IEEE Trans Med Imaging 37:106-115
Alonso, Estella M; Ye, Wen; Hawthorne, Kieran et al. (2018) Impact of Steroid Therapy on Early Growth in Infants with Biliary Atresia: The Multicenter Steroids in Biliary Atresia Randomized Trial. J Pediatr 202:179-185.e4
Visscher, M O; Burkes, S A; Adams, D M et al. (2017) Infant skin maturation: Preliminary outcomes for color and biomechanical properties. Skin Res Technol 23:545-551
Florin, Todd A; Ambroggio, Lilliam; Brokamp, Cole et al. (2017) Reliability of Examination Findings in Suspected Community-Acquired Pneumonia. Pediatrics 140:
Barhight, M; Altaye, M; Gist, K M et al. (2017) Nephrotoxic Medications and Associated Acute Kidney Injury in Very Low Birth Weight Infants. J Clin Nephrol Res 4:
Ambroggio, Lilliam; Florin, Todd A; Shah, Samir S et al. (2017) Emerging Biomarkers of Illness Severity: Urinary Metabolites Associated with Sepsis and Necrotizing Methicillin-Resistant Staphylococcus aureus Pneumonia. Pharmacotherapy 37:1033-1042
Gong, Constance; Byczkowski, Terri; McAneney, Constance et al. (2017) Emergency Department Management of Bronchiolitis in the United States. Pediatr Emerg Care :
Haworth, Kevin J; Bader, Kenneth B; Rich, Kyle T et al. (2017) Quantitative Frequency-Domain Passive Cavitation Imaging. IEEE Trans Ultrason Ferroelectr Freq Control 64:177-191
Rhine, Tara; Babcock, Lynn; Zhang, Nanhua et al. (2016) Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury? Brain Inj 30:1231-8

Showing the most recent 10 out of 48 publications