Columbia University Medical Center's (CUMC) CTSA and Irving Institute for Clinical and Translational Research (IICTR), using the expertise and commitment of faculty in 10 Key Resources have made outstanding progress toward the goal of transforming the culture of ciinicai and translational (C/T) research at CUMC. Examples include: novel projects using interdisciplinary approaches; a novel, 2-phase interdisciplinary pilot award program that has already captured several NIH grants; a Website for all service request that also has a faculty directory that facilitates collaborative research; 5 hours of free consultation to more than 600 investigators leading to 33 NIH grants and 106 publications; collaboration among several CUMC regulatory groups that has significantly improved contracting, IRB time-to-approval, and ethics education/consultation services; successful launch of satellites research facilities in ICUs and EDs resulting in 50 new investigators conducting 30 new protocols; opening ofthe Columbia Community Partnership for Health center, one-half mile from CUMC, as a home for community-based organizations and communitybased participatory research; launching of a new Master's degree in POR, a novel one year certificate curriculum within existing T32 programs, and an outstanding KL2 program with 9 scholars already capturing ndependent funding; and transformation of the old GCRC core laboratory into a campus-wide biomarkers core serving T1, T2 and T3 investigators. Throughout, our Tracking and Evaluation Group has provided critical assistance regarding future direction. Most importantly, we have validated the concept ofthe CTSA and are changing the culture of research at CUMC. In the next 4 years, with institutional support of nearly $4 million yearly, we will build upon this foundation and (1) Expand the resources and infrastructure that we have developed for T2 and T3 clinical researchers; (2) Capitalize on CUMC's outstanding Tl discovery research community by integrating existing resources and investigators even more closely into our CTSA. (3) Improve the health of our community by working with the NYPH ambulatory care network and community based organizations to develop platforms for comparative effectiveness research.
The Clinical and Translational Science Award (CTSA) allows Columbia University to support novel programs whose goal is to speed the translation of scientific discoveries made in the laboratory into new therapies. The CTSA will ensure that these new therapies are accepted by practicing physicians and community members so that we can begin to significantly improve the health of our community and nation.
|Goldberg, Leah R; Kernie, Catherine G; Lillis, Kathleen et al. (2018) Early Recurrence of First Unprovoked Seizures in Children. Acad Emerg Med 25:275-282|
|Faye, Adam S; Mahadev, SriHari; Lebwohl, Benjamin et al. (2018) Determinants of Patient Satisfaction in Celiac Disease Care. J Clin Gastroenterol 52:30-35|
|Rosenbaum, Michael; Heaner, Martica; Goldsmith, Rochelle L et al. (2018) Resistance Training Reduces Skeletal Muscle Work Efficiency in Weight-Reduced and Non-Weight-Reduced Subjects. Obesity (Silver Spring) 26:1576-1583|
|Kalinsky, K; Sparano, J A; Zhong, X et al. (2018) Pre-surgical trial of the AKT inhibitor MK-2206 in patients with operable invasive breast cancer: a New York Cancer Consortium trial. Clin Transl Oncol :|
|Lovinsky-Desir, Stephanie; Lawrence, Jennifer; Jung, Kyung Hwa et al. (2018) Assessment of exposure to air pollution in children: Determining whether wearing a personal monitor affects physical activity. Environ Res 166:340-343|
|Woo Baidal, Jennifer A; Elbel, Erin E; Lavine, Joel E et al. (2018) Associations of Early to Mid-Childhood Adiposity with Elevated Mid-Childhood Alanine Aminotransferase Levels in the Project Viva Cohort. J Pediatr 197:121-127.e1|
|Woo Baidal, Jennifer A; Cheng, Erika R; Rifas-Shiman, Sheryl L et al. (2018) Association of vitamin E intake at early childhood with alanine aminotransferase levels at mid-childhood. Hepatology 67:1339-1347|
|Liu, Ying L; Choi, Christine; Lee, Shing M et al. (2018) Invasive Lobular Breast Carcinoma: Pleomorphic Versus Classical Subtype, Associations and Prognosis. Clin Breast Cancer 18:114-120|
|Wolf, Pavlina; Alcalay, Roy N; Liong, Christopher et al. (2018) Tandem mass spectrometry assay of ?-glucocerebrosidase activity in dried blood spots eliminates false positives detected in fluorescence assay. Mol Genet Metab 123:135-139|
|Nandakumar, Renu; Matveyenko, Anastasiya; Thomas, Tiffany et al. (2018) Effects of mipomersen, an apolipoprotein B100 antisense, on lipoprotein (a) metabolism in healthy subjects. J Lipid Res 59:2397-2402|
Showing the most recent 10 out of 95 publications