The UMN has witnessed unprecedented growth in biomedical research. To improve human health, our clinical and translational science institute (CTSI) will: (1) create a flexible academic infrastructure to coordinate and integrate clinical translational science (CTS) research;(2) foster transparent interactions between UMN and the community;and (3) train and reward CTS interdisciplinary UMN and community teams. Integrated functions and UMN-wide cores include the: (1) Education, Training and Research Career Development Program, supporting CTS research trainees and junior faculty with learner-tailored curricula; (2) Office of Discovery and Translation, accelerating bench-to-bedside translation and commercialization; and (3) Office of Community Engagement for Health, partnering statewide communities and UMN research. Our Biomedical Informatics Function integrates and networks clinical data and bio-specimen resources and cross-CTSI informatics infrastructure, provides training for future informatics scholars, and engages the CTS research community. Our CTSI operates on a platform accessed by an easy access entry (Front Door). Junior investigators will be vigorously supported by: (1) basic science, Tl and T2/T3 Project Development Teams;(2) rapid allocation of junior investigator-dedicated and general pilot funds;and (3) no cost access to (a) all research project managers with preferential assignment to a junior faculty specialist, (b) consultations from the service platform and (c) a junior investigator-dedicated biostatistics advisory team. All CTS mentors will be incentivized, investigators can access general pilot funds, and 3 champions will be supported. For the first time, the Community University Board will engage the UMN and community to discuss high impact health issues. By leveraging CTSA funds, strategic UMN and State investments, our community and major statewide healthcare partner support, electronic networks, special and rural community populations, MN Department of Health, the Mayo Clinic and CTSA collaborators, our CTSI will have a statewide impact on workforce training, healthcare outcomes, and policy. With award of CTSA funds, our innovative CTSI is poised to achieve our long-term goal of better health for individuals, communities, our state, and the world.

Public Health Relevance

The UMN CTSI will improve the health of Minnesotans through CTS research by transforming the relationships among UMN, the community, and the State. Concrete partnerships will facilitate CTS discovery, translation, and knowledge dissemination. Interdisciplinary CTS research teams will be trained using new educational programs and rewarded to meet UMN and identified community needs to impact people's health.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000113-04
Application #
8636505
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Rosenblum, Daniel
Project Start
2011-06-01
Project End
2016-02-29
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
4
Fiscal Year
2014
Total Cost
$1,360,530
Indirect Cost
$100,780
Name
University of Minnesota Twin Cities
Department
Pediatrics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Hui, Susanta; Brunstein, Claudio; Takahashi, Yutaka et al. (2017) Dose Escalation of Total Marrow Irradiation in High-Risk Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 23:1110-1116
Vogel, Rachel Isaksson; Strayer, Lori G; Engelman, Leah et al. (2017) Sun Exposure and Protection Behaviors among Long-term Melanoma Survivors and Population Controls. Cancer Epidemiol Biomarkers Prev 26:607-613
Fein, George; Camchong, Jazmin; Cardenas, Valerie A et al. (2017) Resting state synchrony in long-term abstinent alcoholics: Effects of a current major depressive disorder diagnosis. Alcohol 59:17-25
DiNuzzo, Mauro; Mascali, Daniele; Moraschi, Marta et al. (2017) Temporal Information Entropy of the Blood-Oxygenation Level-Dependent Signals Increases in the Activated Human Primary Visual Cortex. Front Phys 5:
Rosko, Ashley; Wang, Hai-Lin; de Lima, Marcos et al. (2017) Reduced intensity conditioned allograft yields favorable survival for older adults with B-cell acute lymphoblastic leukemia. Am J Hematol 92:42-49
Reddy, Prajwal; Shenoy, Chetan; Blaes, Anne H (2017) Cardio-oncology in the older adult. J Geriatr Oncol 8:308-314
DiNuzzo, Mauro; Giove, Federico; Maraviglia, Bruno et al. (2017) Computational Flux Balance Analysis Predicts that Stimulation of Energy Metabolism in Astrocytes and their Metabolic Interactions with Neurons Depend on Uptake of K(+) Rather than Glutamate. Neurochem Res 42:202-216
Knipping, Friederike; Osborn, Mark J; Petri, Karl et al. (2017) Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification. Mol Ther Methods Clin Dev 4:213-224
Lou, Emil; O'Hare, Patrick; Subramanian, Subbaya et al. (2017) Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments. FEBS J 284:699-707
Hamilton, Betty Ky; Rybicki, Lisa; Abounader, Donna et al. (2017) Allogeneic Hematopoietic Cell Transplantation for Adult T Cell Acute Lymphoblastic Leukemia. Biol Blood Marrow Transplant 23:1117-1121

Showing the most recent 10 out of 261 publications