This revised application for a Clinical and Translational Science Award (CTSA) would support the continued development of the Los Angeles Basin Clinical and Translational Science Institute (CTSI). Our vision is to improve health of the diverse and underserved population of urban Los Angeles and, in doing so, to gain knowledge that we can share with others to improve health in urban settings and megacities across the globe. In pursuit of that vision, we have established a unique partnership of leading academic, clinical and community health organizations in the urban heart of Los Angeles. We are transforming this partnership into a preeminent clinical and translational science institute focused on better heath for diverse, urban communities. We have established four main goals for the CTSI: build on many independent strengths to create an integrated academic home that places high priority on clinical and translational science;create new translational research teams and conduct projects that leverage our unique populations and partnerships to address the best scientific opportunities and most important health priorities of our local communities;transform education and training to create a cadre of people with a major career focus on clinical and translational research;and implement and disseminate what we learn to improve health in our local communities and advance translational research through regional and national networks and collaborations. To achieve these goals, we have assembled an exceptional leadership team that is creating through the CTSI: outstanding resources for active development of new research projects and teams, a robust infrastructure to promote and support basic, clinical and community research, cutting edge methodologies for data acquisition, integration, management and analysis;integrated training of basic, clinical and community researchers using distance education and a focus on research for the diverse communities;aa novel approach to dissemination of our findings using professional communications expertise;and aa professional evaluation group to track and evaluate our progress and impact. Using $3.3M of institutional support, we have already made significant progress in transforming our local environment to a home that highly values clinical and translational research. We demonstrate strong ability to generate and support exciting new research, from the bench to our communities. With a CTSA and a pledge of $18.7M of institutional support over five years, we will expand to a fully functional institute that will have a have a major impact to improve urban health and advance the discipline of clinical and translational research.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000131-05
Application #
8655564
Study Section
Special Emphasis Panel (ZRR1-CR-3 (01))
Program Officer
Sufian, Meryl
Project Start
2010-07-01
Project End
2015-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
5
Fiscal Year
2014
Total Cost
$582,641
Indirect Cost
$59,680
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Shiroishi, Mark S; Cen, Steven Y; Tamrazi, Benita et al. (2016) Predicting Meningioma Consistency on Preoperative Neuroimaging Studies. Neurosurg Clin N Am 27:145-54
Hong, Mingu; Jung, Eunson; Yang, Sara et al. (2016) Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One 11:e0157126
Lekht, Ilya; Brauner, Noah; Bakhsheshian, Joshua et al. (2016) Versatile utilization of real-time intraoperative contrast-enhanced ultrasound in cranial neurosurgery: technical note and retrospective case series. Neurosurg Focus 40:E6
Tamrazi, Benita; Shiroishi, Mark S; Liu, Chia-Shang J (2016) Advanced Imaging of Intracranial Meningiomas. Neurosurg Clin N Am 27:137-43
Burner, Elizabeth; Henderson, Sean O; Burke, Guenevere et al. (2016) Inadequate Sensitivity of Laboratory Risk Indicator to Rule Out Necrotizing Fasciitis in the Emergency Department. West J Emerg Med 17:333-6
Patino, Cecilia M; Kubicek, Katrina; Robles, Marisela et al. (2016) The Community Mentorship Program: Providing Community-Engagement Opportunities for Early-Stage Clinical and Translational Scientists to Facilitate Research Translation. Acad Med :
Guo, Yi; Lebel, R Marc; Zhu, Yinghua et al. (2016) High-resolution whole-brain DCE-MRI using constrained reconstruction: Prospective clinical evaluation in brain tumor patients. Med Phys 43:2013
Shiroishi, Mark S; Boxerman, Jerrold L; Pope, Whitney B (2016) Physiologic MRI for assessment of response to therapy and prognosis in glioblastoma. Neuro Oncol 18:467-78
Russell, Christopher J; Shiroishi, Mark S; Siantz, Elizabeth et al. (2016) The use of inhaled antibiotic therapy in the treatment of ventilator-associated pneumonia and tracheobronchitis: a systematic review. BMC Pulm Med 16:40
Liu, Qinghai; Babadjouni, Robin; Radwanski, Ryan et al. (2016) Stroke Damage Is Exacerbated by Nano-Size Particulate Matter in a Mouse Model. PLoS One 11:e0153376

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