The overall goal of the Mayo Clinic CTSA is to continue to build a broad-based and integrated home for clinical and translational science (CTS) at Mayo Clinic that will ultimately improve human health. In this context, we seek to make the Mayo CTSA and the resources it leverages both an engine of efficiency for clinical and translational research and at the same time a driver of innovation. We also seek to integrate our local activities with consortium wide efforts directed at coordination and alignment. To achieve our goal we have six overarching specific aims for this renewal:
Aim 1 - Train and maintain an outstanding multidisciplinary clinical and translational sciences workforce. This workforce includes teams of both investigators and support staff.
Aim 2 - Eliminate barriers to the work of translation. This will be accomplished through a) continued efforts at regulatory and compliance streamlining, b) provision of outstanding design, biostatistics, and ethics support for investigators, and c) further integration of support services.
Aim 3 - Collaborate with providers and communities to improve health care delivery and community health. This includes substantial commitments to practice-based research, communityengaged research and translating comparative effectiveness research into clinical practice.
Aim 4 - Deploy advanced facilities and other core resources to increase the value of clinical research. With value defined in this context as the quotient of quality and cost, the goal is to increase quality, decrease costs, and provide resources to the full spectrum of clinical and translational investigation.
Aim 5 - Stimulate novel research directions and methodologies by targeted support of innovative pilot and feasibility studies and fostering the development of novel methodologies.
Aim 6 - Employ informatics to integrate and facilitate clinical and translational investigation. This encompasses a broad view of informatics including: a) developing a standardized electronic data capture and analysis tools for CTS, b) robust consultation and tools for medical informatics that leverage Mayo's commitments to electronic clinical systems, and c) bioinformatics services and capabilities that will help facilitate the application of the """"""""new biology"""""""" to clinical and translational investigation. This vision is entirely consistent with the stated mission of Mayo Clinic: """"""""To provide the best care to every patient every day through integrated clinical practice, education, and research.""""""""
Mayo Clinic Center for Translational Science Activities will bring together all the resources of the five schools within the Mayo Clinic College of Medicine and more than 100 years of scientific and medical research expertise, to discover innovative new methods that will speed the translation of research results into therapies, tools, and patient care practices that impact both our local and national communities by improving their health.
|Renfro, Lindsay A; An, Ming-Wen; Mandrekar, Sumithra J (2017) Precision oncology: A new era of cancer clinical trials. Cancer Lett 387:121-126|
|Spencer-Bonilla, Gabriela; Quiñones, Ana R; Montori, Victor M et al. (2017) Assessing the Burden of Treatment. J Gen Intern Med 32:1141-1145|
|Saiki, Hirofumi; Petersen, Ivy A; Scott, Christopher G et al. (2017) Risk of Heart Failure With Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer. Circulation 135:1388-1396|
|Renfro, Lindsay A; Goldberg, Richard M; Grothey, Axel et al. (2017) Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database. J Clin Oncol 35:1929-1937|
|Vallapureddy, Rangit; Lasho, Terra L; Hoversten, Katherine et al. (2017) Nucleophosmin 1 (NPM1) mutations in chronic myelomonocytic leukemia and their prognostic relevance. Am J Hematol 92:E614-E618|
|Patnaik, Mrinal M; Tefferi, Ayalew (2017) Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis (RARS-T): 2017 update on diagnosis, risk-stratification, and management. Am J Hematol 92:297-310|
|Hernandez, Matthew C; Aho, Johnathon M; Habermann, Elizabeth B et al. (2017) Increased anatomic severity predicts outcomes: Validation of the American Association for the Surgery of Trauma's Emergency General Surgery score in appendicitis. J Trauma Acute Care Surg 82:73-79|
|Choudhry, Asad J; Haddad, Nadeem N; Martin, Matthew et al. (2017) Medical Malpractice in Bariatric Surgery: a Review of 140 Medicolegal Claims. J Gastrointest Surg 21:146-154|
|Renfro, Lindsay A; Zhang, Nan; Lopatin, Margarita et al. (2017) Prospective Evaluation of a 12-Gene Assay on Patient Treatment Decisions and Physician Confidence in Mismatch Repair Proficient Stage IIA Colon Cancer. Clin Colorectal Cancer 16:23-30|
|Morrison, Eleshia J; Clark, Matthew M; Wieland, Mark L et al. (2017) Relationship Between Negative Mood and Health Behaviors in an Immigrant and Refugee Population. J Immigr Minor Health 19:655-664|
Showing the most recent 10 out of 118 publications