During the past cycle, following consultation with our internal and external advisory boards, organizational governance structure and the leadership of NCRR, we have focused our efforts on two overarching themes - Translational Therapeutics and Bridging the Pediatric to Adult Divide, taking advantage of resources particular to our institutions. We have fostered interdisciplinary and translational research by a series of """"""""top down"""""""" and """"""""bottom up"""""""" funding initiatives. CTSA support and institutional investment aided by ARRA funding has increased dramatically the footprint of ITMAT more than 7 fold to -150,000 nsf comprising an expanded, integrated and re-purposed Clinical and Translational Research Center (CTRC) that succeeds the Penn and CHOP GCRCs, dry and wet bench laboratory space, a series of cores and a new home for ITMAT educational programs. ITMAT also supports seminars, workshops and an annual international meeting highlighting the opportunities that the CTSA affords on our campus to pursue clinical and translational research. Interdisciplinary research has increased dramatically on, between, and within the partner institutions during the past funding cycle and these trends have been most pronounced amongst members of ITMAT During the coming cycle we envisage the continued growth and development of our educational programs; the continued expansion - via recruitment and education - ofthe critical mass of investigators pursuant of clinical and translational research;enhancement and expansion of our core infrastructure and the development and expansion of programs focused on our two overarching themes. In particular we hope to impact patient care in the community by projecting our two strategic goals to alter the current paradigm of comparative effectiveness research by integrating expertise in basic, pediatric and adult pharmacology and to contribute to predictive strategies in the personalization of medicine.

Public Health Relevance

PENN, CHOP, Monell, Wistar Institute, and the University ofthe Sciences of Philadelphia have benefited greatly from the first cycle of funding of the CTSA, which allowed the development of new centers, research programs, cores and a robust educational program which involve more than 800 investigators across campus and from partner institutions, as well as adding to consortial activities nationally.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000139-08
Application #
8494383
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Boller, Francois
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
8
Fiscal Year
2013
Total Cost
$1,070,798
Indirect Cost
$79,318
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Cielo, Christopher M; Duffy, Kelly A; Vyas, Aesha et al. (2018) Obstructive sleep apnoea and the role of tongue reduction surgery in children with Beckwith-Wiedemann syndrome. Paediatr Respir Rev 25:58-63
Leonard, Charles E; Brensinger, Colleen M; Bilker, Warren B et al. (2017) Gastrointestinal bleeding and intracranial hemorrhage in concomitant users of warfarin and antihyperlipidemics. Int J Cardiol 228:761-770
Cielo, Christopher M; DelRosso, Lourdes M; Tapia, Ignacio E et al. (2017) Periodic limb movements and restless legs syndrome in children with a history of prematurity. Sleep Med 30:77-81
Song, Delu; Sulewski Jr, Michael E; Wang, Chenguang et al. (2017) Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration. Mol Vis 23:210-218
Cielo, Christopher M; Taylor, Jesse A; Vossough, Arastoo et al. (2016) Evolution of Obstructive Sleep Apnea in Infants with Cleft Palate and Micrognathia. J Clin Sleep Med 12:979-87
Egbujo, Chijioke N; Sinclair, Duncan; Hahn, Chang-Gyu (2016) Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia. Curr Psychiatry Rep 18:77
Hartung, Erum A; Kim, Ji Young; Laney, Nina et al. (2016) Evaluation of Neurocognition in Youth with CKD Using a Novel Computerized Neurocognitive Battery. Clin J Am Soc Nephrol 11:39-46
Lin, Jennie; Hu, Yu; Nunez, Sara et al. (2016) Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing. Arterioscler Thromb Vasc Biol 36:1434-47
Cielo, Christopher M; Montalva, Fernando M; Taylor, Jesse A (2016) Craniofacial disorders associated with airway obstruction in the neonate. Semin Fetal Neonatal Med 21:254-62
Ginart, Paul; Kalish, Jennifer M; Jiang, Connie L et al. (2016) Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant. Genes Dev 30:567-78

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