We established the UCSF Clinical and Translational Science Institute (CTSI) at the University of California, San Francisco (UCSF) in 2006 to accelerate the pace of research that improves the health of the public. The overall mission of CTSI has been to improve and transform clinical and translational research infrastructure and training at UCSF and our partner institutions. In the next funding period we aim to use the substantial knowledge, skills, and infrastructure that we have developed to further accelerate the pace of research at UCSF, to export our successes to other institutions, and to create initiatives aimed at improving the health of our own and other communities, through the following aims:
SPECIFIC AIM 1 : To enhance the highly successful activities of the UCSF CTSI, including the development of new initiatives in the areas of Training, Infrastructure/Services, and Advocacy/Culture Change: a) Training: to provide programs for students at all levels, across a spectrum of settings, and including all phases of the improvement of healthcare;b) Infrastructure/Services: to expand services and tools to clinical and translational investigators at UCSF, our partner institutions, and within the broader regional, national, and global communities;and, c) Advocacv/Culture Change: to nurture communication, encourage collaboration, foster innovation, and catalyze the successful conduct of clinical and translational research;to support a diverse faculty;to increase involvement of the community and the responsive of research to its needs;and change the academic culture to promote multidisciplinary, collaborative work.
SPECIFIC AIM 2 : To develop crosscutting initiatives using the knowledge, skills, and infrastructure developed by multiple CTSI programs in the first funding period to accelerate clinical and translational research and its impact on health, well beyond the institutions collaborating in the UCSF CTSI. New initiatives will: a) Bring together local public health and philanthropic groups to work with CTSI to improve the health of the San Francisco Bay Area community through a series of health improvement projects directed at high impact conditions;b) create a model system to accelerate the pace of clinical and translational research that includes streamlining regulation, developing participant recruitment services, providing research management, and bringing research services directly into community practices;and, c) improve the performance, transparency and accountability of research administration within and beyond CTSI by setting challenging goals and tracking performance metrics on public dashboards.
These aims will be achieved by orchestration of activities occurring within and between our 10 programs, supported by a proven governance model, and with strong ties to institutional and community leadership. Our ultimate goal is to bring better health to more people more quickly.

Public Health Relevance

CTSI aims to bring better health to more people more quickly by supporting training, infrastructure, advocacy, and culture change. CTSI achieves this goal not by conducting research but by making it easier for UCSF's superb investigators to conduct research. The current infrastructure and policy environment for clinical and translational research is inefficient, cumbersome and even obstructionist, so CTSI can only meet its goals if it also transforms the way research is done. Its goal is to build innovative infrastructure, tools and services, to transform the core university culture to one which promotes and rewards collaboration and accelerate the clinical application of basic science.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR000143-09
Application #
8737325
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Wilde, David B
Project Start
2006-09-30
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
9
Fiscal Year
2014
Total Cost
$2,858,500
Indirect Cost
$211,741
Name
University of California San Francisco
Department
Other Clinical Sciences
Type
Organized Research Units
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kubo, Ai; Ferrara, Assiamira; Brown, Susan D et al. (2017) Perceived psychosocial stress and gestational weight gain among women with gestational diabetes. PLoS One 12:e0174290
Couch, Elizabeth T; Darius, Ellen; Walsh, Margaret M et al. (2017) Smokeless Tobacco Decision-Making Among Rural Adolescent Males in California. J Community Health 42:544-550
Ionescu, Dawn F; McAdams, Carrie J; O'Donovan, Aoife et al. (2017) Becoming an Academic Researcher in Psychiatry: A View From the Trenches. Acad Psychiatry 41:293-296
Asiodu, Ifeyinwa V; Waters, Catherine M; Dailey, Dawn E et al. (2017) Infant Feeding Decision-Making and the Influences of Social Support Persons Among First-Time African American Mothers. Matern Child Health J 21:863-872
Wysham, Katherine D; Murray, Sara G; Hills, Nancy et al. (2017) Cervical Spinal Fracture and Other Diagnoses Associated With Mortality in Hospitalized Ankylosing Spondylitis Patients. Arthritis Care Res (Hoboken) 69:271-277
Chaffee, Benjamin W; Featherstone, John D B; Zhan, Ling (2017) Pediatric Caries Risk Assessment as a Predictor of Caries Outcomes. Pediatr Dent 39:219-232
Morisset, Julie; Vittinghoff, Eric; Elicker, Brett M et al. (2017) Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model. Chest 152:999-1007
Wilson, Michael R; Suan, Dan; Duggins, Andrew et al. (2017) A novel cause of chronic viral meningoencephalitis: Cache Valley virus. Ann Neurol 82:105-114
Brown, Rebecca T; Diaz-Ramirez, L Grisell; Boscardin, W John et al. (2017) Functional Impairment and Decline in Middle Age: A Cohort Study. Ann Intern Med 167:761-768
Ratanawongsa, Neda; Matta, George Y; Lyles, Courtney R et al. (2017) Multitasking and Silent Electronic Health Record Use in Ambulatory Visits. JAMA Intern Med 177:1382-1385

Showing the most recent 10 out of 298 publications