Three years ago, UCI created the Institute for Clinical and Translational Science (ICTS), which identifies tests, and implements innovative ways to break down barriers that impede biomedical discovery. In the next phase of our concerted effort to transform the UCI clinical research enterprise, our vision is to: 1) Nurture Novel Collaborations-The ICTS builds multidisciplinary research teams, such as chemists and clinicians exploring breath biomarkers in the human """"""""ventilome."""""""" ICTS experts in the science of team science will help new partnerships to identify and remove obstacles to successful collaboration before they become insurmountable. 2) Create New Technologies for Translational Science-^The ICTS made novel UCI-based technologies such as biophotonics and microdevices available to a new generation of clinicians. We will now develop and provide new methodologies by partnering with UCI information scientists in the use of ubiquitous computing for field research;with nursing and social scientists for qualitative and comparative effectiveness research;and with exercise physiologists and molecular biologists for technologies that link genomic information with dynamic disease phenotypes. 3) Share Information-The ICTS has engaged clinicians, hospital IT staff, and scholars from the School of Information and Computer Sciences to create the Center for Biomedical Informatics. We are now ready to embed infrastructure for clinical data interoperability at a unique moment, namely, as UCI begins to deploy its EMR;4) Engage Our Community-The ICTS championed new approaches such as PEER (Participant Experience Enhancement in Research), a program that views research volunteers as partners in the process of discovery. We plan a range of outreach/dissemination activities, from mitigating elder abuse to preventing sudden death in pediatric athletes. And 5) Train-^We will implement Crossing BoLindaries, a set of degree and certificate programs along with mentorship interaction that tackles key issues in translational science. Finally, we view ourselves as part of a unique translational science network for Southern California, in which the resources of regional academic medical centers are integrated to better realize the overarching vision of the CTSA.
UCI is becoming a motivating force for clinical research in this dynamic region of Southern California. The ICTS will support a wide range of projects that will benefit public health, including the ambitious NIH-funded National Childen's Study;research into rare, poorly studied diseases of mitochondrial origin;and community outreach efforts to mitigate the health consequences of obesity among underinsured people in our region.
|Guner, Yigit S; Nguyen, Danh V; Zhang, Lishi et al. (2017) Development and Validation of Extracorporeal Membrane Oxygenation Mortality-Risk Models for Congenital Diaphragmatic Hernia. ASAIO J :|
|Bhakta, Savita G; Light, Gregory A; Talledo, Jo A et al. (2017) Tolcapone-Enhanced Neurocognition in Healthy Adults: Neural Basis and Predictors. Int J Neuropsychopharmacol 20:979-987|
|Grill, Joshua D; Holbrook, Andrew; Pierce, Aimee et al. (2017) Attitudes toward Potential Participant Registries. J Alzheimers Dis 56:939-946|
|Wilson, Robert H; Crouzet, Christian; Torabzadeh, Mohammad et al. (2017) High-speed spatial frequency domain imaging of rat cortex detects dynamic optical and physiological properties following cardiac arrest and resuscitation. Neurophotonics 4:045008|
|Robles, Lourdes; Vaziri, Nosratola D; Li, Shiri et al. (2016) Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis. Pancreas 45:720-9|
|Gohil, Shruti K; Cao, Chenghua; Phelan, Michael et al. (2016) Impact of Policies on the Rise in Sepsis Incidence, 2000-2010. Clin Infect Dis 62:695-703|
|Choi, Sarah E; Ngo-Metzger, Quyen; Billimek, John et al. (2016) Contributors to Patients' Ratings of Quality of Care Among Ethnically Diverse Patients with Type 2 Diabetes. J Immigr Minor Health 18:382-9|
|Gohil, Shruti K; Okubo, Sandra; Klish, Stephen et al. (2016) Healthcare Workers and Post-Elimination Era Measles: Lessons on Acquisition and Exposure Prevention. Clin Infect Dis 62:166-172|
|Tran, Minh-Ha; Foster, Clarence E; Kalantar-Zadeh, Kamyar et al. (2016) Kidney transplantation in obese patients. World J Transplant 6:135-43|
|Scott, Shruti K; Gohil, Shruti K; Quan, Kathleen et al. (2016) Marked reduction in compliance with central line insertion practices (CLIP) when accounting for missing CLIP data and incomplete line capture. Am J Infect Control 44:242-4|
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