One of medicine's greatest challenges today is the efficient, seamless translation of biomedical research discoveries into clinical applications. New methodologies, technologies and integrated information systems offer unprecedented promise for discovery and growth. Yet, significant barriers confound our ability to extract essential knowledge from these burgeoning research platforms. The University of Colorado at Denver and Health Sciences Center (UCDHSC) and our Affiliates (6 major hospitals and health care institutions serving our region, the University of Colorado at Boulder, and local communities) are committed to transforming our aligned enterprise to meet these challenges. In response to the NIH Roadmap Initiative RM-07-007, UCDHSC and Affiliates are creating the Colorado Clinical and Translational Sciences Institute (CCTSI). This transformation will be achieved, with substantial institutional support, through 4 Specific Goals: ^Transformation of the Institution: The CCTSI will be the integrated and interdisciplinary statewide academic home for the disciplines of clinical and translational sciences and research. 2) Transformation of the Clinical and Translational Scientist: The CCTSI will enhance, integrate and transform training of translational scientists, to develop a new generation of investigators with advanced degrees, interdisciplinary and collaborative skills and a team approach to scientific investigation. 3) Transformation of Discovery Translational Research: The CCTSI will transform the performance of bench-to-beside research by providing new resources and infrastructure, integrating current and developing new innovative research tools and methodologies, catalyzing new interdisciplinary research programs, and removing barriers to efficiency. 4) Transformation of Community Translational Research and Practice: This will be performed by enhancing, extending and integrating community-based participatory research into programs that will engage community participation and develop novel methodologies and informatics platforms for translation of discoveries into practice. Implicit to the success of these programs will be a rigorous ongoing self-evaluation to ensure the most productive use of resources. These programs will be centralized on the new Anschutz Medical Campus, constructed in its entirety over the last 10 years, in which adjacencies of all Health Science Schools, research facilities and a biomedical corporate park create the ideal environment for success.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
3KL2TR000156-05S1
Application #
8664962
Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Purucker, Mary E
Project Start
2008-05-19
Project End
2013-10-31
Budget Start
2012-06-06
Budget End
2013-10-31
Support Year
5
Fiscal Year
2013
Total Cost
$1
Indirect Cost
$22,585
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Chen, Huanhuan Joyce; Miller, Paula; Shuler, Michael L (2018) A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells. Lab Chip 18:2036-2046
Horton, K W; Carlson, N E; Grunwald, G K et al. (2017) A population-based approach to analyzing pulses in time series of hormone data. Stat Med 36:2576-2589
Miller, Paula G; Wang, Ying I; Swan, Glen et al. (2017) A simple cell transport device keeps culture alive and functional during shipping. Biotechnol Prog 33:1257-1266
Ivy, Dunbar (2016) Pulmonary Hypertension in Children. Cardiol Clin 34:451-72
Sakolish, Courtney M; Esch, Mandy B; Hickman, James J et al. (2016) Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges. EBioMedicine 5:30-9
Wang, Chao; Trongnetrpunya, Amy; Samuel, Immanuel Babu Henry et al. (2016) Compensatory Neural Activity in Response to Cognitive Fatigue. J Neurosci 36:3919-24
Huebschmann, Amy G; Campbell, Lucille Johnson; Brown, Candace S et al. (2016) ""My hair or my health:"" Overcoming barriers to physical activity in African American women with a focus on hairstyle-related factors. Women Health 56:428-47
Abaci, Hasan Erbil; Gledhill, Karl; Guo, Zongyou et al. (2015) Pumpless microfluidic platform for drug testing on human skin equivalents. Lab Chip 15:882-8
Abaci, Hasan Erbil; Shuler, Michael L (2015) Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol (Camb) 7:383-91
Chandler, Joshua D; Min, Elysia; Huang, Jie et al. (2015) Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol 53:193-205

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