One of medicine's greatest challenges today is the efficient, seamless translation of biomedical research discoveries into clinical applications. New methodologies, technologies and integrated information systems offer unprecedented promise for discovery and growth. Yet, significant barriers confound our ability to extract essential knowledge from these burgeoning research platforms. The University of Colorado at Denver and Health Sciences Center (UCDHSC) and our Affiliates (6 major hospitals and health care institutions serving our region, the University of Colorado at Boulder, and local communities) are committed to transforming our aligned enterprise to meet these challenges. In response to the NIH Roadmap Initiative RM-07-007, UCDHSC and Affiliates are creating the Colorado Clinical and Translational Sciences Institute (CCTSI). This transformation will be achieved, with substantial institutional support, through 4 Specific Goals: ^Transformation of the Institution: The CCTSI will be the integrated and interdisciplinary statewide academic home for the disciplines of clinical and translational sciences and research. 2) Transformation of the Clinical and Translational Scientist: The CCTSI will enhance, integrate and transform training of translational scientists, to develop a new generation of investigators with advanced degrees, interdisciplinary and collaborative skills and a team approach to scientific investigation. 3) Transformation of Discovery Translational Research: The CCTSI will transform the performance of bench-to-beside research by providing new resources and infrastructure, integrating current and developing new innovative research tools and methodologies, catalyzing new interdisciplinary research programs, and removing barriers to efficiency. 4) Transformation of Community Translational Research and Practice: This will be performed by enhancing, extending and integrating community-based participatory research into programs that will engage community participation and develop novel methodologies and informatics platforms for translation of discoveries into practice. Implicit to the success of these programs will be a rigorous ongoing self-evaluation to ensure the most productive use of resources. These programs will be centralized on the new Anschutz Medical Campus, constructed in its entirety over the last 10 years, in which adjacencies of all Health Science Schools, research facilities and a biomedical corporate park create the ideal environment for success.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
3KL2TR000156-05S1
Application #
8664962
Study Section
Special Emphasis Panel (ZRR1-SRC (99))
Program Officer
Purucker, Mary E
Project Start
2008-05-19
Project End
2013-10-31
Budget Start
2012-06-06
Budget End
2013-10-31
Support Year
5
Fiscal Year
2013
Total Cost
$1
Indirect Cost
$22,585
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Holden, Samantha K; Jones, Wallace E; Baker, Keith A et al. (2016) Outcome measures for Parkinson's disease dementia: a systematic review. Mov Disord Clin Pract 3:9-18
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Wang, Chao; Trongnetrpunya, Amy; Samuel, Immanuel Babu Henry et al. (2016) Compensatory Neural Activity in Response to Cognitive Fatigue. J Neurosci 36:3919-24
Sakolish, Courtney M; Esch, Mandy B; Hickman, James J et al. (2016) Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges. EBioMedicine 5:30-9
Caverly, Lindsay J; Caceres, Silvia M; Fratelli, Cori et al. (2015) Mycobacterium abscessus morphotype comparison in a murine model. PLoS One 10:e0117657
Abaci, Hasan Erbil; Shuler, Michael L (2015) Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling. Integr Biol (Camb) 7:383-91
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Wang, Chao; Ding, Mingzhou; Kluger, Benzi M (2015) Functional Roles of Neural Preparatory Processes in a Cued Stroop Task Revealed by Linking Electrophysiology with Behavioral Performance. PLoS One 10:e0134686
Chandler, Joshua D; Min, Elysia; Huang, Jie et al. (2015) Antiinflammatory and Antimicrobial Effects of Thiocyanate in a Cystic Fibrosis Mouse Model. Am J Respir Cell Mol Biol 53:193-205

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