In 2007, the University of Alabama at Birmingham (UAB) and its affiliates completed three important, large- scale strategic planning efforts. Together, these processes generated a """"""""blueprint for our research future"""""""" that lays the foundation to transform our substantial clinical and translational research enterprise through integration and innovation across all disciplines, Schools, and our health care system. This transformation will be driven by the UAB Center for Clinical and Translational Science (CCTS). The CCTS vision is to transform the UAB environment by building productive and efficient interdisciplinary research teams through educational ingenuity, regulatory reorganization, resource coordination, and methodological innovation. The mission is to develop a transformative infrastructure that spans the spectrum from preclinical research to bench-to-bedside translation (T1 research) to community implementation (T2 research), and will meet 5 goals: 1) transform the Investigator;2) transform the Training Environment;3) transform the Resource Infrastructure;4) transform the Approach to Interdisciplinary Research via an emphasis on outcomes research and health disparities research;and 5) establish a new Research Model through the Self-Monitoring and Improvement Program. To meet these goals, the CCTS will rely on: 1) a re-organized reporting structure that assures the PI full institutional support in implementing the CCTS roadmap;2) a revised CCTS leadership that includes faculty from the Schools of Medicine, Public Health, Nursing, Health Professions, and Optometry;and 3) innovative partnerships involving UAB, Southern Research Institute (our affiliated, not-for-profit research organization for preclinical drug discovery/development), the Children's Health System, the HudsonAlpha Institute for Biotechnology, the greater Birmingham community, and a long-standing collaborative network that involves Historically Black Colleges and Universities (HBCUs) and underprivileged communities in our region. UAB, the Health System, Health Services Foundation, Research Foundation, and Southern Research Institute have made substantial commitments to the CCTS including: 1) significant new funding for the clinical and translational research infrastructure (~$150 million, of which over $18 million are directly for CCTS activities and programs);2) a redesigned and enhanced biomedical informatics infrastructure;and 3) over 20,000 sf of prime clinical and administrative space. When combined, the re-organized^ CCTS governance and leadership, the substantial commitment of funds and resources, the interdisciplinary culture of UAB, and the new CCTS programs, will create a transformed environment for clinical and translational research that will benefit our trainees, investigators, patients, community, and the national CTSA effort.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Special Emphasis Panel (ZRR1-SRC (99))
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Sawczuk, Andrea
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University of Alabama Birmingham
Internal Medicine/Medicine
Schools of Medicine
United States
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Askenazi, David J; Faubel, Sarah (2017) The Nephrologist Has Great Potential to Have an Important Role in the Intensive Care Unit: Reply to the Letter to the Editor of David J.R. Morgan. Blood Purif 44:269-270
Gerstenecker, Adam; Niccolai, Lindsay; Marson, Daniel et al. (2016) Enhancing Medical Decision-Making Evaluations: Introduction of Normative Data for the Capacity to Consent to Treatment Instrument. Assessment 23:232-9
Gerstenecker, Adam; Martin, Roy; Marson, Daniel C et al. (2016) Introducing demographic corrections for the 10/36 Spatial Recall Test. Int J Geriatr Psychiatry 31:406-11
Triebel, Kristen L; Gerstenecker, Adam; Meneses, Karen et al. (2015) Capacity of patients with brain metastases to make treatment decisions. Psychooncology 24:1448-55
Gerstenecker, Adam; Meneses, Karen; Duff, Kevin et al. (2015) Cognitive predictors of understanding treatment decisions in patients with newly diagnosed brain metastasis. Cancer 121:2013-9
Gerstenecker, Adam; Duff, Kevin; Meneses, Karen et al. (2015) Cognitive Predictors of Reasoning through Treatment Decisions in Patients with Newly Diagnosed Brain Metastases. J Int Neuropsychol Soc 21:412-8
Skidmore, F M; Spetsieris, P G; Anthony, T et al. (2015) A full-brain, bootstrapped analysis of diffusion tensor imaging robustly differentiates Parkinson disease from healthy controls. Neuroinformatics 13:7-18
Lo, Alexander X; Donnelly, John P; McGwin Jr, Gerald et al. (2015) Impact of gait speed and instrumental activities of daily living on all-cause mortality in adults ?65 years with heart failure. Am J Cardiol 115:797-801
Askenazi, David; Patil, Neha R; Ambalavanan, Namasivayam et al. (2015) Acute kidney injury is associated with bronchopulmonary dysplasia/mortality in premature infants. Pediatr Nephrol 30:1511-8
Gerstenecker, Adam; Nabors, Louis B; Meneses, Karen et al. (2014) Cognition in patients with newly diagnosed brain metastasis: profiles and implications. J Neurooncol 120:179-85