The University of Chicago (UC) Institute for Translational Medicine (ITM) was created in 2007 to assemble, integrate, and create the intellectual, administrative, and physical resources required to catalyze research and research training in Clinical and Translational Science. Its ultimate goals are to train scientists and health care providers at UC and in our community to determine the molecular, genetic, pathophysiologic and social determinants of disease and disease predisposition in individuals; to test interventions directed toward those mechanisms; and to achieve these goals in a way that is rigorous, efficient, ethical, respectful of, and responsive to our community's needs and values. In its first 4 years, the ITM has capitalized on the outstanding intellectual and physical resources throughout the University and ait ITM affiliate Institutions, Argonne National Laboratory, North Shore University Health System, Illinois Institute of Technology, and Access Community Health Network, and on substantial institutional and CTSA financial investments, to build the infrastructure for a transformative, energized, and self-improving home for clinical and translational research. The impact of the ITM has been greatest in 5 domains: 1) catalyzing the formation of multidisciplinary research teams; 2) establishing a systematic, organized clinical and translational research infrastructure; 3) engaging our community in research; 4) training for careers in clinical and translational team science; and 5) impact on and contributions to the National CTSA Consortium. Building on these, we propose to expand research and training opportunities with five major initiatives: a new TI Research and Technology Cluster; new Cores in Comparative Effectiveness Research and in Social, Environmental, and non-Biological Determinants of Health; a Personalizing Medicine initiative; a new Entrepreneurship Training and Support Program; and a Nurse-rScientist Training Program at new ITM affiliate Rush University. These programs, strengthened by community advice, engagement, partnership and participation, will ensure continued transformation of clinical and translational science at the University of Chicago and affiliates, on the South Side of Chicago, and beyond.

Public Health Relevance

This program leverages the expertise of University of Chicago and affiliated investigators in a broad array of clinical and nonclinical fields to prepare the next generation of clinical and translational researchers to engage with our community partners to identify and prioritize a translational research agenda, and to address and reduce clinical health disparities in diverse adult and pediatric populations in our Community.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sufian, Meryl
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Volerman, Anna; Dennin, Margaret; Vela, Monica et al. (2018) A qualitative study of parent perspectives on barriers, facilitators and expectations for school asthma care among urban, African-American children. J Asthma :1-11
Chor, Julie; Tusken, Megan; Young, Danielle et al. (2018) Factors Shaping Women's Pre-abortion Communication with Members of Their Social Network. J Community Health :
Pinto, Jayant M; Wroblewski, Kristen E; Huisingh-Scheetz, Megan et al. (2017) Global Sensory Impairment Predicts Morbidity and Mortality in Older U.S. Adults. J Am Geriatr Soc 65:2587-2595
Volerman, Anna; Ignoffo, Stacy; Hull, Ashley et al. (2017) Identification of students with asthma in Chicago schools: Missing the mark. Ann Allergy Asthma Immunol 118:739-740
Fu, Jiao; Fujisawa, Haruki; Follman, Benjamin et al. (2017) Thyroid Hormone Metabolism Defects in a Mouse Model of SBP2 Deficiency. Endocrinology 158:4317-4330
Berman, Mitchell E; Fanning, Jennifer R; Guillot, Casey R et al. (2017) Effect of alcohol dose on deliberate self-harm in men and women. J Consult Clin Psychol 85:854-861
Volerman, Anna; Chin, Marshall H; Press, Valerie G (2017) Solutions for Asthma Disparities. Pediatrics 139:
Gao, Jianjun; Davis, Lea K; Hart, Amy B et al. (2017) Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology 42:811-821
Lee, Royce; Arfanakis, Konstantinos; Evia, Arnold M et al. (2016) White Matter Integrity Reductions in Intermittent Explosive Disorder. Neuropsychopharmacology 41:2697-703
Hanlon, Erin C; Tasali, Esra; Leproult, Rachel et al. (2016) Sleep Restriction Enhances the Daily Rhythm of Circulating Levels of Endocannabinoid 2-Arachidonoylglycerol. Sleep 39:653-64

Showing the most recent 10 out of 65 publications