The Clinical and Translational Science Collaborative (CTSC) of Cleveland is a collaborative venture among five Cleveland health institutions - Case Western Reserve University, the Cleveland Clinic, University Hospitals, MetroHealth Medical Center, and the Veterans Administration Medical Center, as well as community partners. CTSC achieved prior goals of uniting as a collaborative, developed informatics tools, resource sharing, and institutional commitments to enhance the collaborative. Consolidation and catalytic activities begun in the last grant period will be continued. Moreover, CTSC will continue rigorous evaluation of both its operations and progress toward larger goals. CTSC has set three new goals for the next grant period.'1) Translation 1 research will be enhanced. Infrastructure in support of identification and structural determination of therapeutic targets, as well as high through put screening will be implemented. Support systems to assist in patient based research both recruitment and testing will be streamlined and strengthened. Critically, CTSC will create support systems to guide development of potential human therapeutics and diagnostics from discovery to use in man, 2) CTSC will improve health parameters in Cleveland, one of America's poorest and least healthy cities. Community Research Partnership Core is querying the community via neighborhood focus groups to determine their health priorities. At least one of these priorities, and others selected based on the strengths of our CTSC investigative community, will be targeted for special effort. One practice based research network has already succeeded in reducing HgbAlc in 27,000 diabetics in Cleveland by one percentage point in three years, raising optimism that this project can indeed move the needle. 3) CTSC interactions with the national CTSA community will increase. The initial focus of CTSC was inward, establishing connections and catalyzing change in our home institutions, but in the next grant period the CTSC will increase interactions around the consortium. A primary focus will be the Ohio Consortium of the three Ohio CTSAs (CTSC, Columbus, Cincinnati), which currently collaborate surrounding child health and cancer projects, and on the web site NetWellness, which has been expanded from simply providing unbiased medical information to include descriptions of clinical research and access to clinical trials. In the next grant period goals will include extending the CTSC IRB electronic hub for facilitated review to include the other CTSA sites, increasing project collaboration, and connecting patient databases via Explorys, a web based informatics tool utilizing the electronic health record.

Public Health Relevance

The CTSC is highly relevant to human health. Using the Cleveland biomedical community as a prototype, we will develop and test electronic and other strategies for coordinating research functions among different institutions, such as IRB approval and facile data sharing. Using the Cleveland community as a laboratory and our practice based research networks and community partnership resource as tools, we will seek to improve health parameters in Cleveland. We will also develop more facile means for Translation 1.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Special Emphasis Panel (ZRR1)
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Davis Nagel, Joan
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Case Western Reserve University
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United States
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Dalton, Jarrod E; Dawson, Neal V; Sessler, Daniel I et al. (2016) Empirical Treatment Effectiveness Models for Binary Outcomes. Med Decis Making 36:101-14
Hamilton, Jesse I; Jiang, Yun; Chen, Yong et al. (2016) MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density. Magn Reson Med :
Ontaneda, Daniel; Fox, Robert J (2016) Imaging as an Outcome Measure in Multiple Sclerosis. Neurotherapeutics :
Sweet, Jennifer A; Pace, Jonathan; Girgis, Fady et al. (2016) Computational Modeling and Neuroimaging Techniques for Targeting during Deep Brain Stimulation. Front Neuroanat 10:71
Dalton, Jarrod E; Zidar, David A; Udeh, Belinda L et al. (2016) Practice Variation Among Hospitals in Revascularization Therapy and Its Association With Procedure-related Mortality. Med Care 54:623-31
Wong, Francis; Namdari, Bahram; Dupler, Suzanne et al. (2016) No difference in pain reduction after epidural steroid injections in diabetic versus nondiabetic patients: A retrospective cohort study. J Anaesthesiol Clin Pharmacol 32:84-8
Misra-Hebert, Anita D; Hu, Bo; Taksler, Glen et al. (2016) Financial Incentives and Diabetes Disease Control in Employees: A Retrospective Cohort Analysis. J Gen Intern Med 31:871-7
Itrat, Ahmed; Taqui, Ather; Cerejo, Russell et al. (2016) Telemedicine in Prehospital Stroke Evaluation and Thrombolysis: Taking Stroke Treatment to the Doorstep. JAMA Neurol 73:162-8
Taksler, Glen B; Kiszko, Kamila; Abrams, Courtney et al. (2016) Adults Who Order Sugar-Sweetened Beverages: Sociodemographics and Meal Patterns at Fast Food Chains. Am J Prev Med 51:890-897
Dorand, R Dixon; Nthale, Joseph; Myers, Jay T et al. (2016) Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity. Science 353:399-403

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