This CTSA renewal application is built on the research infrastructure, training programs, and partnerships we established in the first grant period, through creation of the Institute for Clinical and Translational Sciences (ICTS), which brought about significant cultural and organizational changes at Washington University in St. Louis and unprecedented collaboration between its partner institutions, including BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University of Missouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-Jewish College, and the St. Louis College of Pharmacy. The overall goal of this application is to promote the translation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical and translational research, expand and enhance clinical and translational research education programs, and promote communication and collaborative research with regional and national partners. New initiatives include 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result in high-impact clinical research and its subsequent translation into clinical practice: translating the findings of genetic/genomic research into clinical research and practice, accelerating the development and evaluation of new therapeutics, and conducting comparative effectiveness and dissemination and implementation research to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space and financial support. Barnes-Jewish Hospital and St. Louis Children's Hospital, our academic hospital partners, and BJC HealthCare, our affiliated health system, have also made substantial commitments to support the clinical and translational research activities of the ICTS. This institutional support, combined with the programs and collaborations we have started in the past four years, ensure that the ICT^S will continue to make outstanding contributions in clinical and translational science.

Public Health Relevance

The overall goal of this grant is to promote the translation of scientific discoveries into improvements in human health. Our proposal will improve clinical research infrastructure, services, and training programs in order to speed the translation of new discoveries from the lab into humans, and to help implement the best medical evidence into clinical practice.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Mentored Career Development Award (KL2)
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Study Section
Special Emphasis Panel (ZRR1-CR-1 (01))
Program Officer
Sawczuk, Andrea
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Washington University
Internal Medicine/Medicine
Schools of Medicine
Saint Louis
United States
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Tsevat, Danielle G; Wiesenfeld, Harold C; Parks, Caitlin et al. (2017) Sexually transmitted diseases and infertility. Am J Obstet Gynecol 216:1-9
Dhar, Rajat (2017) Neurologic Complications of Transplantation. Neurocrit Care :
Stranges, Paul M; Vouri, Scott M (2017) Impact of co-investigators on pharmacy resident research publication. Pharm Pract (Granada) 15:928
Rao, Rakesh; Trivedi, Shamik; Vesoulis, Zachary et al. (2017) Safety and Short-Term Outcomes of Therapeutic Hypothermia in Preterm Neonates 34-35 Weeks Gestational Age with Hypoxic-Ischemic Encephalopathy. J Pediatr 183:37-42
Waddell, Kimberly J; Strube, Michael J; Bailey, Ryan R et al. (2017) Does Task-Specific Training Improve Upper Limb Performance in Daily Life Poststroke? Neurorehabil Neural Repair 31:290-300
Ong, Charlene Jennifer; Gluckstein, Jeffrey; Laurido-Soto, Osvaldo et al. (2017) Enhanced Detection of Edema in Malignant Anterior Circulation Stroke (EDEMA) Score: A Risk Prediction Tool. Stroke 48:1969-1972
Oldenburg, Catherine E; Nunn, Amy S; Montgomery, Madeline et al. (2017) Behavioral Changes Following Uptake of HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in a Clinical Setting. AIDS Behav :
Patel, Rupa R; Harrison, Laura C; Patel, Viraj V et al. (2017) HIV Pre-exposure Prophylaxis Programs Incorporating Social Applications Can Reach At-Risk Men Who Have Sex With Men for Successful Linkage to Care in Missouri, USA. J Assoc Nurses AIDS Care 28:428-430
Schindler, Suzanne E; Jasielec, Mateusz S; Weng, Hua et al. (2017) Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease. Neurobiol Aging 56:25-32
Stamatakis, Katherine A; Ferreira Hino, Adriano Akira; Allen, Peg et al. (2017) Results from a psychometric assessment of a new tool for measuring evidence-based decision making in public health organizations. Eval Program Plann 60:17-23

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