This CTSA renewal application is built on the research infrastructure, training programs, and partnerships we established in the first grant period, through creation of the Institute for Clinical and Translational Sciences (ICTS), which brought about significant cultural and organizational changes at Washington University in St. Louis and unprecedented collaboration between its partner institutions, including BJC HealthCare, Barnes-Jewish Hospital, St. Louis Children's Hospital, Saint Louis University, University of Missouri - St. Louis, Southern Illinois University Edwardsville, Goldfarb School of Nursing at Barnes-Jewish College, and the St. Louis College of Pharmacy. The overall goal of this application is to promote the translation of scientific discoveries into improvements in human health.
Our specific aims will transform our research support infrastructure to foster multidisciplinary clinical and translational research, expand and enhance clinical and translational research education programs, and promote communication and collaborative research with regional and national partners. New initiatives include 3 new cross-cutting scientific themes where the resources of our ICTS are most likely to result in high-impact clinical research and its subsequent translation into clinical practice: translating the findings of genetic/genomic research into clinical research and practice, accelerating the development and evaluation of new therapeutics, and conducting comparative effectiveness and dissemination and implementation research to improve the transfer of research into practice. To ensure the continued success of the ICTS, WU has made significant commitments of space and financial support. Barnes-Jewish Hospital and St. Louis Children's Hospital, our academic hospital partners, and BJC HealthCare, our affiliated health system, have also made substantial commitments to support the clinical and translational research activities of the ICTS. This institutional support, combined with the programs and collaborations we have started in the past four years, ensure that the ICT^S will continue to make outstanding contributions in clinical and translational science.
The overall goal of this grant is to promote the translation of scientific discoveries into improvements in human health. Our proposal will improve clinical research infrastructure, services, and training programs in order to speed the translation of new discoveries from the lab into humans, and to help implement the best medical evidence into clinical practice.
|Burnham, Jason P; Kwon, Jennie H; Olsen, Margaret A et al. (2018) Readmissions With Multidrug-Resistant Infection in Patients With Prior Multidrug Resistant Infection. Infect Control Hosp Epidemiol 39:12-19|
|Salloum, Naji C; Buchalter, Erica Lf; Chanani, Swati et al. (2018) From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation. Pharmacogenomics 19:861-871|
|Mayer, Kenneth H; Chan, Philip A; R Patel, Rupa et al. (2018) Evolving Models and Ongoing Challenges for HIV Preexposure Prophylaxis Implementation in the United States. J Acquir Immune Defic Syndr 77:119-127|
|Smith, Gordon I; Commean, Paul K; Reeds, Dominic N et al. (2018) Effect of Protein Supplementation During Diet-Induced Weight Loss on Muscle Mass and Strength: A Randomized Controlled Study. Obesity (Silver Spring) 26:854-861|
|Kafashan, MohammadMehdi; Palanca, Ben Julian A; Ching, ShiNung (2018) Dimensionality reduction impedes the extraction of dynamic functional connectivity states from fMRI recordings of resting wakefulness. J Neurosci Methods 293:151-161|
|Estabrooks, Paul A; Brownson, Ross C; Pronk, Nicolaas P (2018) Dissemination and Implementation Science for Public Health Professionals: An Overview and Call to Action. Prev Chronic Dis 15:E162|
|El Ters, Nathalie M; Mathur, Amit M; Jain, Siddharth et al. (2018) Long term electroencephalography in preterm neonates: Safety and quality of electrode types. Clin Neurophysiol 129:1366-1371|
|Oldenburg, Catherine E; Nunn, Amy S; Montgomery, Madeline et al. (2018) Behavioral Changes Following Uptake of HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in a Clinical Setting. AIDS Behav 22:1075-1079|
|Vesoulis, Zachary Andrew; Liao, Steve M; Rao, Rakesh et al. (2018) Re-examining the arterial cord blood gas pH screening criteria in neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 103:F377-F382|
|Chen, Li-Shiun; Horton, Amy; Bierut, Laura (2018) Pathways to precision medicine in smoking cessation treatments. Neurosci Lett 669:83-92|
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