To fulfill the new NCATS vision for the CTSA Consortium and accelerate scientific discoveries into improved outcomes for patients, academic health and science systems must invest, transform, and innovate to optimize their unique strengths. Our vision, aligned with that of NCATS, is to create a research environment at Duke that stimulates the translation of scientific discovery from bench to bedside by 1) linking discovery science to a creative engine that efficiently accelerates development of new technologies; and 2) integrating clinical trials, registries, and electronic health records in a learning health system where research and practice form a continuum. Our research environment will be driven by scientific merit and societal need, agnostic to disease or specialty discipline, aligned with our updated institutional framework for research oversight and quality, and continually evaluated for academic productivity, efficiency, and cost. To achieve these goals, we will create an Integrated Home for clinical and translational research by providing infrastructure and resources to serve investigators and trainees across the research spectrum. We will offer resources based upon common needs among our researchers, including education, biostatistics, biobanking, regulatory expertise, ethics, pilot funding and recruitment assistance. We will also tailor our offerings to specialized needs across research communities that include early translation, proof of concept, site-based research and population' based research, which includes multi-site trials, outcomes, health services, implementation science and community engaged research. Integrating these resources will require a new tool, a portal for all trainees and investigators, MyResearchHome(gDuke, and its human counterpart, MyResearchTeam(gDuke. These tools will provide a single point of entry for all clinical and translational research at Duke, regardless of their department or school. Thus, we will enhance our Integrated Home for clinical and translational research with a combination of sophisticated information technology and mentoring and navigation; provide access to common and specialized resources for all of our translational research communities and train the next generation of researchers in our educational and training programs.
The CTSA will foster the translational research process, ensuring that new discoveries are developed and evaluated more quickly and that clinical research is done with high quality, efficiency, safety and cost- effectiveness.
|Hall, Rasheeda K; Luciano, Alison; Pieper, Carl et al. (2018) Association of Kidney Disease Quality of Life (KDQOL-36) with mortality and hospitalization in older adults receiving hemodialysis. BMC Nephrol 19:11|
|Lunyera, Joseph; Davenport, Clemontina A; Bhavsar, Nrupen A et al. (2018) Nondepressive Psychosocial Factors and CKD Outcomes in Black Americans. Clin J Am Soc Nephrol 13:213-222|
|Elsamadicy, Aladine A; Yang, Siyun; Sergesketter, Amanda R et al. (2018) Prevalence and Cost Analysis of Complex Regional Pain Syndrome (CRPS): A Role for Neuromodulation. Neuromodulation 21:423-430|
|Grotegut, Chad A; Lewis, Lauren L; Manuck, Tracy A et al. (2018) The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study. Am J Perinatol 35:78-83|
|DeFilipp, Zachariah; Peled, Jonathan U; Li, Shuli et al. (2018) Third-party fecal microbiota transplantation following allo-HCT reconstitutes microbiome diversity. Blood Adv 2:745-753|
|Feng, Liping; Allen, Terrence K; Marinello, William P et al. (2018) Roles of Progesterone Receptor Membrane Component 1 in Oxidative Stress-Induced Aging in Chorion Cells. Reprod Sci :1933719118776790|
|Hall, Rasheeda K; Sloane, Richard; Pieper, Carl et al. (2018) Competing Risks of Fracture and Death in Older Adults with Chronic Kidney Disease. J Am Geriatr Soc 66:532-538|
|Cary Jr, Michael P; Hall, Rasheeda K; Anderson, Amber L et al. (2018) Management Team Perceptions of Risks and Strategies for Preventing Falls Among Short-Stay Patients in Nursing Homes. Health Care Manag (Frederick) 37:76-85|
|Neacsiu, Andrada D; Rompogren, Joscelyn; Eberle, Jeremy W et al. (2018) Changes in Problematic Anger, Shame, and Disgust in Anxious and Depressed Adults Undergoing Treatment for Emotion Dysregulation. Behav Ther 49:344-359|
|Elsamadicy, Aladine A; Ashraf, Bilal; Ren, Xinru et al. (2018) Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation. Neuromodulation :|
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