San Antonio, the gateway to South Texas, is the 7"^ largest city in the US and the largest metropolitan area with a majority Hispanic population (63%). South Texas is about the size of Ohio, and comprises an impoverished and largely Hispanic population with disproportionate rates of diabetes and obesity, exacerbated by a lack of health insurance and poor access to health care. This region also contains numerous US military installations, and active-duty service members and veterans often have special health issues, including increased risk for post-traumatic stress disorder and traumatic injuries. Unfortunately, neither better access to care nor improved care delivery can eliminate health disparities and meet these complex needs. In addition, research across the full T l to T4 translational spectrum is required to eliminate knowledge gaps and establish real-world effectiveness that improves health cai^e for our populations. In 2006, UTHSCSA established the Institute for Integration of Medicine and Science (IIMS) to improve health and reduce disparities by accelerating scientific discoveries and applications across the full translational research spectrum. For example, IIMS expanded the number of clinical research units that extend to the Texas-Mexico border from 1 to 7, and dramatically increasing participant access to clinical and translational science. We increased, from 2 to 6, the Practice-Based Research Networks that focus on diverse ambulatory populations. Efforts to address translational science workforce needs over the past 5-10 years have graduated 100 Masters Clinical Investigation students, supported 19 successful KL2 Scholars, and established new joint Translational Science PhD and Certificate programs. In this proposal, we provide strategies to spur clinical and translational science evolution, catalyze research teams, and implement programs that produce creative, collaborative, and culturally diverse scientists.
Our Specific Aims will: 1. Accelerate clinical and translational research innovation and effective team science along the entire T1 to 14 research spectrum by providing an academic home integrated with our strategic partner institutions. 2. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists. 3. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, and reduce costs across all IIMS programs.

Public Health Relevance

; Based on our vision of improving the health status of South Texas by accelerating scientific discoveries and public health applications, we will deploy strategic resources that focus on prevalent challenges in our region, including: 1) the health needs of our underserved Hispanic population, 2) the special health issues facing active-duty military and veteran populations, and 3) limitations in the translational science workforce required to fill in critical knowledge gaps and improve health in South Texas and the US.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
1KL2TR001118-01
Application #
8721515
Study Section
Special Emphasis Panel (ZAI1-PTM-C (S1))
Program Officer
Sawczuk, Andrea
Project Start
2013-09-26
Project End
2018-04-30
Budget Start
2013-09-26
Budget End
2014-04-30
Support Year
1
Fiscal Year
2013
Total Cost
$376,425
Indirect Cost
$27,883
Name
University of Texas Health Science Center San Antonio
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Li, Wei; Long, Justin Alexander; Watts, Lora et al. (2016) Spatiotemporal changes in diffusion, T2 and susceptibility of white matter following mild traumatic brain injury. NMR Biomed 29:896-903
El-Sakka, Abeer; Penon, Cristina; Hegazy, Adham et al. (2016) Evaluating Bone Health in Egyptian Children with Forearm Fractures: A Case Control Study. Int J Pediatr 2016:7297092
Fucich, Elizabeth A; Paredes, Denisse; Morilak, David A (2016) Therapeutic Effects of Extinction Learning as a Model of Exposure Therapy in Rats. Neuropsychopharmacology 41:3092-3102
Talley Watts, Lora; Long, Justin Alexander; Boggs, Robert Cole et al. (2016) Delayed Methylene Blue Improves Lesion Volume, Multi-Parametric Quantitative Magnetic Resonance Imaging Measurements, and Behavioral Outcome after Traumatic Brain Injury. J Neurotrauma 33:194-202
Foster, Byron A; Aquino, Christian A; Gil, Mario et al. (2016) A Pilot Study of Parent Mentors for Early Childhood Obesity. J Obes 2016:2609504
Villanueva, Gabriela Abigail; Foster, Byron Alexander (2016) Factors Associated with Successful Mentoring of Parents Addressing Childhood Obesity: A Mixed Methods Approach. Int J Pediatr 2016:5769621
Schwacha, Martin G; Rani, Meenakshi; Nicholson, Susannah E et al. (2016) Dermal γδ T-Cells Can Be Activated by Mitochondrial Damage-Associated Molecular Patterns. PLoS One 11:e0158993
Teshome, Besu F; Lee, Grace C; Reveles, Kelly R et al. (2015) Application of a methicillin-resistant Staphylococcus aureus risk score for community-onset pneumonia patients and outcomes with initial treatment. BMC Infect Dis 15:380
Foster, Byron A; Aquino, Christian; Gil, Mario et al. (2015) A randomized clinical trial of the effects of parent mentors on early childhood obesity: Study design and baseline data. Contemp Clin Trials 45:164-9
Mansi, Ishak; Frei, Christopher R; Wang, Chen-Pin et al. (2015) Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults. J Gen Intern Med 30:1599-610

Showing the most recent 10 out of 124 publications