The most effective chemotherapeutic regimen for small cell lung cancer is combination Cisplatin and Etoposide. A major problem with this regimen is the significant toxicity. The primary toxicity of Etoposide is bone marrow suppression. The toxicities of Cisplatin include nephro, neuro, myelo, and GI toxicity. DDTC inhibits the binding of platinum compounds to biologically useful substrates without inhibiting the antitumor effects of the agent.

Project Start
Project End
Budget Start
Budget End
Support Year
33
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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