Preliminary studies initially suggest that hyperinsulinemia contributes to the anovulation of the clomiphene resistant patient and to anovulation in general. Measures to reduce serum insulin such as metformin, could be used as adjunctive therapy with clomiphene to induce ovulation in women resistant to clomiphene alone. Results would also show which patients would benefit from metformin. In addition, the possibility is raised that these measures could reduce the dosage of clomiphene used, increase the number of anovulatory patients requiring gonadotropin injections with associated high cost, inconvenience, and increased multiple gestation and ovarian hyperstimulation tests.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000032-40
Application #
6406934
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
1978-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2000
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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