This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primary goal of this study is to compare brain activity in response to food but not non-food stimuli of lean and obese subjects while fasted and fed. This study will allow us to determine whether there are differences in brain activity under stimulation with food between lean and obese individuals that may explain obesity. Twelve lean and twelve obese women will be recruited to participate. All subjects will undergo a thorough screening procedure to evaluate their mental status and possible presence of any metal within their body. Subjects will undergo two scanning visits separated by two weeks at the Department of Cardiology. Prior to both scanning visits the subjects must be in a fasted state. While in the scanner, subjects will view or touch foods or objects in random order within several periods of 4-6 minutes each. Each food or object will be viewed or touched for a period of 4 s. Subjects will view or touch 40-60 foods and objects during each period. Foods and objects used in this study will be selected based on ease of recognition and appeal and will not be messy or magnetic. Subjects will be required to lie in the magnet without moving their head for the total duration of the scanning procedures. These procedures should last approximately 40-90 minutes. On the occasion where a meal will be served, subjects will be asked to consume the formula meal in 15 minutes and scanning will take place 30 minutes later. Following the scans, the subjects will be asked to rate whether they liked or disliked the foods and objects viewed and touched during the study.
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