There are, currently, no accepted sensitive and specific biological markersof total dietary fat intake for use in epidemiologic studies. By examining a combiantion of fatty acids, found in low concentrations, reflecting various components of a low fat diet, it may be possible to develop a marker of fat intake. This was tested in a 7 week controlled dietary intervention in 61 post menopausal women, randomized to either a 17% or 34 % fat calories diet. There were highly significant (P<0.001) increases in relative proportions of many erythrocyte and/or plasma phospholipid fatty acids which differentiated the two groups very well. These findings are highly promising but there a number issues which need to be resolved. We propose to extend the study to other populations while looking at fatty acid changes over time, weight loss and body composition.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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