The objectives of this study are: 1) to determine the optimal efficacious dose at which Trocade when administered against background therapy of MTX, a NSAID and corticosteroid (if required) prevents structural damage to articular joints; 2) to determine if Trocade when administered against background therapy can improve or stablize clinical signs and symptoms, disability or quality of life; 3) to determine the safety of Trocade when administered against background therapy of MTX and/or NSAID and/or steroids; 4) to investigate the pharmacokinetics of Trocade when administered against background therapy.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
General Clinical Research Centers Program (M01)
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University of North Carolina Chapel Hill
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United States
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