This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.In this study, the PI will examine features of coagulation that lead to bleeding or thrombosis. She will examine procoagulant activity of blood cells. She will perform these studies using a TF-initiated model system of coagulation that utilized stimulated monoctyes. freshly isolated platelets and purified coagulation proteins and correlate parameters of thrombin generation, platelet activation and fibrin clot structure. Five to 50 ml of blood will be drawn from a vein in the subject's arm. Monocytes and platelets will be isolated from the blood and used in subsequent in vitro experiments. The activity of monocytes, platelet activation and thrombin generation under a variety of conditions in vitro will be examined.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000046-47
Application #
7625665
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-12-01
Project End
2007-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
47
Fiscal Year
2007
Total Cost
$375
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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