Childhood obstructive sleep apnea syndrome (OSAS) appears to be due to a combination onf structural and neuromotor factors. It is thought that those children who develop OSAS due to adenotonsillar hypertrophy have additional underlying abnormalities. Magnetic resonance imaging (MRI) studies have shown that adults with OSAS have narrow upper airways compared to controls. It is therefore possible that those children with adenotonsillar hypertrophy and OSAS have narrower upper airways than children with large tonsils but no OSAS. MRIs have also been useful in adults to demonstrate the degree of adipose tissue encroachment on the upper airway. In children, MRIs can be used to measure the size of the upper airway, and establish whether upper airway narrowing, if present, is due to skeletal structures, adipose tissue or lymphoid tissue (tonsils and adenoids). We therefore performed MRIs of the upper airway in 4 children with OSAS (3 of whom received CPAP therapy) and 2 controls. Two studies were technically inadequate due to patient motion (sedation cannot be used in children with OSAS). In the remaining subjects, children with OSAS had smaller upper airways than controls. These very preliminary datat suggest that children with OSAS have small pharyngeal airways, and suggest that the patients may be at risk of recurrence of OSAS in leter life, should they develop additional risk factors.

Project Start
1997-03-05
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
36
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Jiamsakul, Awachana; Kariminia, Azar; Althoff, Keri N et al. (2017) HIV Viral Load Suppression in Adults and Children Receiving Antiretroviral Therapy-Results From the IeDEA Collaboration. J Acquir Immune Defic Syndr 76:319-329
Chen, Teresa K; Appel, Lawrence J; Grams, Morgan E et al. (2017) APOL1 Risk Variants and Cardiovascular Disease: Results From the AASK (African American Study of Kidney Disease and Hypertension). Arterioscler Thromb Vasc Biol 37:1765-1769
Kadakia, Kunal C; Kidwell, Kelley M; Seewald, Nicholas J et al. (2017) Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors. Breast Cancer Res Treat 164:411-419
Criado, Kristen K; Sharp, William G; McCracken, Courtney E et al. (2017) Overweight and obese status in children with autism spectrum disorder and disruptive behavior. Autism :1362361316683888
Scherzer, Rebecca; Heymsfield, Steven B; Rimland, David et al. (2017) Association of serum albumin and aspartate transaminase with 5-year all-cause mortality in HIV/hepatitis C virus coinfection and HIV monoinfection. AIDS 31:71-79
Chen, Teresa K; Tin, Adrienne; Peralta, Carmen A et al. (2017) APOL1 Risk Variants, Incident Proteinuria, and Subsequent eGFR Decline in Blacks with Hypertension-Attributed CKD. Clin J Am Soc Nephrol 12:1771-1777
Wang, Sibao; Dos-Santos, André L A; Huang, Wei et al. (2017) Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria. Science 357:1399-1402
Hertz, D L; Kidwell, K M; Seewald, N J et al. (2017) Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer. Pharmacogenomics J 17:521-527
Muzaale, A D; Althoff, K N; Sperati, C J et al. (2017) Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors. Am J Transplant 17:1823-1832
Pisciotta, John M; Scholl, Peter F; Shuman, Joel L et al. (2017) Quantitative characterization of hemozoin in Plasmodium berghei and vivax. Int J Parasitol Drugs Drug Resist 7:110-119

Showing the most recent 10 out of 1004 publications