This study will be used to validate dynamic PET imaging of 18FDG uptake in muscle for measurement of glucose transport and phosphorylation. Once the technique is validated it will be used to assess glucose transport in the insulin resistance associated with NIDDM and obesity. Results from the PET studies will be related to immunohistochemical studies in which Glut 4 is labeled and identified by quantitative confocal laser microscopy imaging of vastus laterialis muscle obtained by percutaneous biopsy.

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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